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A study of multiple sclerosis patients with magnetic resonance spectroscopic imaging

Departments of Radiology, PO Box 50000, NL-7500 KA Enschede, The Netherlands

JAG Geelen

Neurology, Medisch Spectrum Twente, PO Box 50000, NL-7500 KA Enschede, The Netherlands

JA denBoer

Departments of Radiology, PO Box 50000, NL-7500 KA Enschede, The Netherlands

RL Prevo

Departments of Radiology, PO Box 50000, NL-7500 KA Enschede, The Netherlands

JM Minderhoud

Department of Neurology, University Hospital Groningen, PO Box 30001, NL-9700 RB Groningen, The Netherlands

EJ 's-Gravenmade

Department of Neurology, University Hospital Groningen, PO Box 30001, NL-9700 RB Groningen, The Netherlands

Eleven patients with clinically definite MS and three healthy controls were investigated by magnetic resonance spectroscopic imaging. The data sets were analysed for all voxels containing white matter only. We classify these voxels in healthy controls as normal white matter (NWM), and in MS patients as normal-appearing white matter unaffected by MS lesions (NAWM) or white matter affected by MS lesions. The spectra belonging to the voxels were analysed for content of cholines, creatines and N-ocetylasportote (NAA), and compared as a group. It was found that lesions differ from white matter in chemical composition and, moreover, that normal-appearing white matter differs from healthy white matter. Specifically, levels of NAA are lower in patients. There seems to be a linear relation between the composition of white matter and the expanded disability status scale value for the patient The presence of lactate could not be established, and no unambiguous differences were found between patients with relapsing-remitting and relapsing-progressive disease.

Key Words: magnetic resonance imaging methods • multiple sclerosis metabolism • brain-pathology • brain-chemistry

Multiple Sclerosis, Vol. 1, No. 1, 25-31 (1995)
DOI: 10.1177/135245859500100105


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