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Depression before and after diagnosis of multiple sclerosis

Departments of Psychology and Psychiatry, Dalhousie University, Nova Scotia, Canada

B Weinshenker

Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA

S Mikail

Department of Psychology, The Rehabilitation Centre, Ottawa, Canada

K Edgley

Department of Psychology, University of Ottawa, Canada

Depression was examined in 45 patients evaluated within 2 months of diagnosis of MS. At the time of testing, 40% of the MS sample met the diagnostic criteria for major depression, 22% had adjustment disorder with depressed mood and 37% showed no evidence of mood disorder. Personal and family history of depression in patients with MS was also examined and compared with a sample of patients with chronic low back pain (CLBP) who were matched for age, gender, marital and employment status and current level of depression. Fifty-two per cent of patients whit MS reported experiencing a depressive episode before the onset of MS compared with 17% of patients with CLBP (P<0.001). Sixteen patients with MS (35%) reported family history (parent or sibling) of treatment for depression compared with seven (15%) of patients with CLBP (P<0.05). MS patients with a history of depression reported more initial symptoms than MS patients without a history of depression. Clinical and theoretical implications of the findings are discussed.

Key Words: depression • diagnosis • chronic pain

Multiple Sclerosis, Vol. 1, No. 2, 104-108 (1995)
DOI: 10.1177/135245859500100208


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