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Clinical and subclinical neurological involvement in children of conjugal multiple sclerosis patients

Departments of Neurology

RI Grossman

Departments of Radiology

PF Finelli

Department of Neurology, Hartford Hospital, Hartford, CT

M Kamoun

Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA

C Zmijewski

Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA

JA Cohen

Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH, USA

We report the occurrence of clinically definite multiple sclerosis in an offspring of a couple with conjugal multiple sclerosis. Extensive investigation of all members of this family, which includes two additional asymptomatic children, eliminated the possibility of alternative neurological diagnoses. All family members were studied with magnetic resonance imaging (MRI), evoked potentials, and human leukocyte antigen (HLA) typing. An asymptomatic child had subtle white matter abnormalities on MRI, suggesting subclinical neurological involvement This study documents the third case of multiple sclerosis in the child of conjugal multiple sclerosis patients and provides the first report of MRI lesions in an asymptomatic offspring of the same parents. Neurodiagnostic and immunogenetic investigations of such rare family clusters may contribute to the elucidation of the pathogenesis of multiple sclerosis.

Key Words: conjugal multiple sclerosis • familial multiple sclerosis • genetic susceptibility • MRI • HLA

Multiple Sclerosis, Vol. 1, No. 3, 170-172 (1995)
DOI: 10.1177/135245859500100307


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