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The evolutionary relationship among Caucasian MS patients and controls

Department of Neurology

H Alder

Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, USA

UF Bosch

Department of Neurology

FD Lublin

Department of Neurology

D Chatterjee

Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, USA

Previous observations suggest that the mitochondrial (mt)DNA may confer susceptibility to multiple sclerosis (MS). However, the proportion of affected individuals and the range of contributing mtDNA abnormalities are unknown. To help clarify this question, we analyzed the first hypervariable D-loop sequences of the mtDNA in a group of randomly selected Caucasian MS patients, in MS patients with prominent optic neuritis (PON) and in controls. Phylogenetic analysis of these D-loop sequences revealed that individuals in both groups of patients are generally scattered in the Caucasian phylogeny. However, a small cluster of unrelated MS patients identified by this analysis suggests that a maternal lineage with MS relevant mtDNA sequences may exist, and merits a more comprehensive study.

Key Words: mitochondrial DNA • genetic relationship

Multiple Sclerosis, Vol. 1, No. 5, 288-295 (1996)
DOI: 10.1177/135245859600100505


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