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Multiple Sclerosis
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Inhibitors of tumor necrosis factor-{alpha}: Promising agents for the treatment of multiple sclerosis?

Reinhard Hohlfeld

Department of Neurology, Klinikum Groβhadern, University of Munich, D-81366 Munich and Department of Neuroimmunology, Max-Planck Institute, D-82152 Martinsried, Germany

Tumor necrosis factor (TNF)-{alpha} is a critical inflammatory mediator of experimental autoimmune encephalomyelitis and multiple sclerosis, and may therefore be a useful target for immunotherapy. Therapeutic strategies aimed at TNF include pharmacological inhibitors of TNF synthesis and/or processing and biological inhibitors of TNF effects. Several anti-TNF agents are currently being tested in multiple sclerosis in pilot clinical trials.

Key Words: multiple sclerosis • tumor necrosis factor-{alpha} • immunotherapy

Multiple Sclerosis, Vol. 1, No. 6, 376-378 (1996)
DOI: 10.1177/135245859600100619
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