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Multiple Sclerosis
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Remyelination of the central nervous system

Alastair Compston

University of Cambridge Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ and MRC Cambridge Centre for Brain Repair, ED Adrian Building, University Forvie Site, Robinson Way, Cambridge CB2 2PY, UK

The three typical stages in the clinical course of multiple sclerosis (relapse, persistent disability and progression) can be explained on the basis of inflammation, demyelination and failure of repair leading to axon degeneration and astrocytosis. Strategies ore being evaluated for limiting the inflammatory process using immunological treatments and these may have unexpected dividends in promoting endogenous remyelination. Increasing knowledge on glial lineages and axon-glial interactions needed for stable myelination also offer the prospect for enhancing remyelination through growth factor therapy and cell implantation.

Key Words: Multiple sclerosis • oligodendrocytes • myelination • cell implantation • remyelination

Multiple Sclerosis, Vol. 1, No. 6, 388-392 (1996)
DOI: 10.1177/135245859600100622
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