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Oligoclonal bands in Devic’s neuromyelitis optica and multiple sclerosis: differences in repeated cerebrospinal fluid examinations

Centre for Multiple Sclerosis, Neurological Institute ‘IRCCS C. Mondino’, University of Pavia, Pavia, Italy, roberto.bergamaschi{at}mondino.it

S Tonietti

Centre for Multiple Sclerosis, Neurological Institute ‘IRCCS C. Mondino’, University of Pavia, Pavia, Italy

D Franciotta

Laboratory of Neuroimmunology, Neurological Institute ‘IRCCS C. Mondino’, University of Pavia, Pavia, Italy

E Candeloro

Centre for Multiple Sclerosis, Neurological Institute ‘IRCCS C. Mondino’, University of Pavia, Pavia, Italy

E Tavazzi

Centre for Multiple Sclerosis, Neurological Institute ‘IRCCS C. Mondino’, University of Pavia, Pavia, Italy

G Piccolo

Centre for Multiple Sclerosis, Neurological Institute ‘IRCCS C. Mondino’, University of Pavia, Pavia, Italy

A Romani

Centre for Multiple Sclerosis, Neurological Institute ‘IRCCS C. Mondino’, University of Pavia, Pavia, Italy

V Cosi

Centre for Multiple Sclerosis, Neurological Institute ‘IRCCS C. Mondino’, University of Pavia, Pavia, Italy

We studied repeated cerebrospinal fluids of patients with Devic’s neuromyelitis optica (NMO) and multiple sclerosis (MS). Variations of oligoclonal bands (OBs) had opposite trends in the two groups. In MS, O Bs were detected in 399 of 411 patients (97%) and never disappeared. In NMO, O Bs were detected in three of 11 patients (27%) and always disappeared. The hypothesis that NMO and MS follow distinct patho genetic pathways is supported by our findings, which can be useful for the differentiatio n of NMO from MS.

Key Words: cerebrospinal fluid • Devic’s syndrome • multiple sclerosis • neuromyelitis optica • oligoclonal bands

Multiple Sclerosis, Vol. 10, No. 1, 2-4 (2004)
DOI: 10.1191/1352458504ms988oa


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