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No evidence for genetic linkage between development of multiple sclerosis and components of the IFN system and the JA K-STAT pathway

Department of Neurology, University Hospital, SE-221 85 Lund, Sweden, My.Bergkvist{at}neurol.lu.se

M Olsson

Department of Mathematics, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden

M Sandberg-Wollheim

Department of Neurology, University Hospital, SE-221 85 Lund, Sweden

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS). Several observations suggest that the interferon system may be of interest in the study of MS development. To investigate whether polymorphism in components of the IFN system and the JA K-STAT pathway influence susceptibility to MS, we performed a linkage analysis between polymorphic loci in or close to the IFN gamma, IFN gamma recepto r, IFN alpha/beta recepto r, JA K 1, STAT 1 and STAT 3 genes in 27 Swedish families with at least two members having MS. Tests for transmission disequilibrium and nonparametric linkage analysis gave negative results. We found no evidence for linkage between MS and any of these loci.

Key Words: interferon • JA K-STAT • linkage • multiple sclerosis • polymorphism

Multiple Sclerosis, Vol. 10, No. 1, 87-88 (2004)
DOI: 10.1191/1352458504ms976sr


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