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Cerebrospinal fluid levels of brain specific proteins in optic neuritis

Department of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, UK

D Grant

Department of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, UK

M Pashenkov

Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, SE-14186, Sweden

G Keir

Department of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, UK

E J Thompson

Department of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, UK

M Söderström

Department of Ophthalmology, Karolinska Institute, Huddinge University Hospital, Stockholm, SE-14186, Sweden

G Giovannoni

Department of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, UK, G.Giovannoni{at}ion.ucl.ac.uk

This study evaluates levels of cerebrospinal fluid (C SF) brain-specific proteins (BSP) in subjects with optic neuritis (O N) who are at high risk of progression to multiple sclerosis (MS). Forty-one subjects had acute O N and 17 subjects with other neurological diseases (OND) served as controls. Twenty-o ne subjects with O N had white matter lesions on magnetic resonance imaging (MRI) and intrathecal synthesis of oligoclonal IgG bands (OB) consistent with being at high risk of progression to MS; eight of whom later were diagnosed with clinically definite MS (C DMS). Levels of S100B, ferritin and two neurofilament heavy chain phosphoforms (NfH^SMI34 and NfH^SMI35) were analysed using ELISA technique. A putative index of ‘axonal health’ was expressed as a ratio of NfH^SMI34 to NfH^SMI35. NfH^SMI34 and the NfHSMI34:SMI35 were significantly elevated in subjects with O N compared to controls. No significant differences in levels of C SF BSP were seen between O N subjects with C DMS plus those at high risk of progression to MS and O N subjects with normal MRI and negative C SF analysis. In conclusion, there is evidence of axonal damage in subjects who present with O N, which is independent of the diagnosis of C DMS.

Key Words: axonal damage • ferritin • multiple sclerosis • neurofilament heavy chain phosphoforms • optic neuritis • phosphorylation • S100B

Multiple Sclerosis, Vol. 10, No. 3, 261-265 (2004)
DOI: 10.1191/1352458504ms1020oa


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