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Association of apolipoprotein E and myeloperoxidase genotypes to clinical course of familial and sporadic multiple sclerosis

Department of Neurology, The Medical University of Warsaw, 02-097 Warsaw, Banacha 1A, Str., Poland, beza{at}amwaw.edu.pl

M Styczynska

Department of Neurodegenerative Diseases, Medical Research Centre, Polish Academy of Sciences

A Podlecka

Department of Neurology, The Medical University of Warsaw, 02-097 Warsaw, Banacha 1A, Str., Poland

R Samocka

Department of Neurology, CSK MSWiA, 02-507 Warsaw, Woloska 137, Str., Poland

B Peplonska

Department of Neurodegenerative Diseases, Medical Research Centre, Polish Academy of Sciences

M Barcikowska

Department of Neurodegenerative Diseases, Medical Research Centre, Polish Academy of Sciences

H Kwiecinski

Department of Neurology, The Medical University of Warsaw, 02-097 Warsaw, Banacha 1A, Str., Poland

The importance of apolipoprotein E (ApoE) and myeloperoxidase (MPO) genotypes in the clinical characteristics of multiple sclerosis (MS) has been recently emphasized. In a large group of Polish patients we have tested the hypothesis that polymorphism in ApoE and MPO genes may influence the course of the disease. G enotypes were determined in 117 MS patients (74 females and 43 males; 99 sporadic and 18 familial cases) with mean EDSS of 3.6, mean age of 44.1 years, mean duration of the disease 12.8 years and mean onset of MS at 31.2 years, and in 100 healthy controls. The relationship between ApoE and MPO genes’ polymorphism and the MS activity as well as the defect of remyelination (diffuse demyelination) and brain atrophy on MRI were analysed. The ApoE o4 allele was not related to the disease course or the ApoE o2 to the intensity of demyelination on MRI. The genotype MPO G/G was found in all familial MS and in 57% (56/99) of sporadic cases. This genotype was also related to more pronounced brain atrophy on MRI. The MPO G/G subpopulation was characterized by a significantly higher proportion of patients with secondary progressive MS (PB- 0.05) and by a higher value of EDSS. A ccording to our results the MPO G allele is frequently found (in 96% of cases) among Polish patients with MS. More severe nervous tissue damage in the MPO G/G form can be explained by the mechanism of accelerated oxidative stress. It seems that MPO G/G genotype may be one of the genetic factors influencing the progression rate of disability in MS patients.

Key Words: apolipoprotein E • genes • multiple sclerosis • myeloperoxidase • polymorphism

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