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Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA

Steven Z Pavletic

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA, pavletis{at}mail.nih.gov

Jinan Al-Omaishi

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA

M Patricia Leuschen

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA, Department of Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA

Samuel J Pirruccello

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA

Mary L Filipi

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA

Charles Enke

Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA

Mary Margaret Ursick

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA

Francis Hahn

Department of Radiology, University of Nebraska Medical Center, Omaha, NE, USA

J D Bowen

Department of Neurology, University of Washington, Seattle, WA, USA

Richard A Nash

Fred Hutchinson Cancer Research Center of the University of Washington, Seattle, WA, USA

This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and C SF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantatio n strategies for this disease.

Key Words: autologous stem cell transplantation • functional outcomes • multiple sclerosis

Multiple Sclerosis, Vol. 10, No. 3, 284-289 (2004)
DOI: 10.1191/1352458504ms1022oa


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