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Multiple sclerosis following treatment with a cannabinoid receptor-1 antagonist

Department of Neurology, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, the Netherlands, bw.vanoosten{at}vumc.nl

J Killestein

Department of Neurology, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, the Netherlands

E MH Mathus-Vliegen

Department of Gastroenterology and Hepatology, Academic Medical Centre, P.O. Box 22700, 1100 DE Amsterdam, the Netherlands

C H Polman

Department of Neurology, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, the Netherlands

Laboratory research including animal models of human disease suggests that cannabinoids might have therapeutic potential in multiple sclerosis (MS). We have recently seen a 46-year-old woman who developed MS after starting treatment with a cannabino id recepto r antagonist for obesity. The occurrence of MS several months after starting a cannabinoid receptor antagonist suggests that the cannabino id system might indeed be relevant to disease pathogenesis in MS.

Key Words: appetite depressants • cannabinoid receptor antagonist • endogenous cannabinoids • multiple sclerosis • obesity

Multiple Sclerosis, Vol. 10, No. 3, 330-332 (2004)
DOI: 10.1191/1352458504ms1044oa


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