This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by van Oosten, B W Articles by Polman, C H Search for Related Content PubMed PubMed Citation Articles by van Oosten, B W Articles by Polman, C H Social Bookmarking                         What's this?

Multiple sclerosis following treatment with a cannabinoid receptor-1 antagonist

Department of Neurology, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, the Netherlands, bw.vanoosten{at}vumc.nl

J Killestein

Department of Neurology, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, the Netherlands

E MH Mathus-Vliegen

Department of Gastroenterology and Hepatology, Academic Medical Centre, P.O. Box 22700, 1100 DE Amsterdam, the Netherlands

C H Polman

Department of Neurology, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, the Netherlands

Laboratory research including animal models of human disease suggests that cannabinoids might have therapeutic potential in multiple sclerosis (MS). We have recently seen a 46-year-old woman who developed MS after starting treatment with a cannabino id recepto r antagonist for obesity. The occurrence of MS several months after starting a cannabinoid receptor antagonist suggests that the cannabino id system might indeed be relevant to disease pathogenesis in MS.

Key Words: appetite depressants • cannabinoid receptor antagonist • endogenous cannabinoids • multiple sclerosis • obesity

Multiple Sclerosis, Vol. 10, No. 3, 330-332 (2004)
DOI: 10.1191/1352458504ms1044oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A.H. Taylor, C. Ang, S.C. Bell, and J.C. Konje The role of the endocannabinoid system in gametogenesis, implantation and early pregnancy Hum. Reprod. Update, September 1, 2007; 13(5): 501 - 513. [Abstract] [Full Text] [PDF]

				P. Pacher, S. Batkai, and G. Kunos The Endocannabinoid System as an Emerging Target of Pharmacotherapy Pharmacol. Rev., September 1, 2006; 58(3): 389 - 462. [Abstract] [Full Text] [PDF]