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Overview of London trial of intramuscular interferon-b1a in primary-progressive multiple sclerosis

Institute of Neurology, Queen Square, London, WC1N 3BG, UK, d.miller{at}ion.ucl.ac.uk

Siobhan M Leary

Institute of Neurology, Queen Square, London, WC1N 3BG, UK

Alan J Thompson

Institute of Neurology, Queen Square, London, WC1N 3BG, UK

This short monograph describes the rationale, design and outcome of a pilot study of beta interferon in patients with primary progressive MS. A total of 50 patients were studied for 2 years using a randomized, double-blinded, placebo -controlled design. There was an emphasis on using MRI measures to evaluate outcome. The study showed that with the numbers studied, useful data could be obtained on safety and on efficacy on certain MRI measures. A larger study would be required to evaluate treatment on disability in this patient cohort and further work is needed to elucidate the relationship between quantitative MR and clinical measures over the longer term.

Key Words: primary progressive MS • pilot trial • MRI • beta interferon

Multiple Sclerosis, Vol. 10, No. 3 suppl, S56-S57 (2004)
DOI: 10.1191/1352458504ms1031oa


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