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Multiple Sclerosis
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CD8 + T cells reduce in vitro interferon-g production in Theiler’s murine encephalomyelitis virus-induced demyelinating disease model

Paul W Denton

UT Southwestern Medical Center, Division of Infectious Diseases, 5323 Harry Hines Boulevard, Dallas, TX 75390-9113, USA

Christina M Tello

Department of Microbiology and Immunology, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203-9037, USA

Roger W Melvold

Department of Microbiology and Immunology, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203-9037, USA, rmelvold{at}medicine.nodak.edu

In the Theiler’s murine encephalomyelitis virus (TMEV)-induced demyelinating disease model for multiple sclerosis, regulatory CD8- T cells prevent demyelinating disease and reducein vivo interferon (IFN)-g production by anti-TMEV CD4- blast cells in BALB/c mice. We describe here that regulatory CD8- T cells reduce in vitro IFN-g production by lymph node cells from both TMEV and fowl gamma globulin immunized mice without affecting interleukin (IL)-4, IL-10, tumour growth factor-b or tumour necrosis factor-a production.

Key Words: autoimmune demyelination • interferon-{gamma} • multiple sclerosis • regulatory CD8+T cells • TMEV

Multiple Sclerosis, Vol. 10, No. 4, 370-375 (2004)
DOI: 10.1191/1352458504ms1054oa
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