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Decreased MMP-9 production in primary progressive multiple sclerosis patients

Unitat de Neuroimmunologia Clínica, Hospital Vall d’Hebron, Barcelona, Espanya, jsastre{at}hg.vhebron.es

M Comabella

Unitat de Neuroimmunologia Clínica, Hospital Vall d’Hebron, Barcelona, Espanya

L Brieva

Unitat de Neuroimmunologia Clínica, Hospital Vall d’Hebron, Barcelona, Espanya

A Rovira

Unitat de Ressonància Magne`tica, Hospital Vall d’Hebron, Barcelona, Espanya

M Tintoré

Unitat de Neuroimmunologia Clínica, Hospital Vall d’Hebron, Barcelona, Espanya

X Montalban

Unitat de Neuroimmunologia Clínica, Hospital Vall d’Hebron, Barcelona, Espanya

Background: An increase in MMP-9 levels has been found in relapsing-remitting (RR) multiple sclerosis (MS) showing correlation with magnetic resonance (MR) parameters mainly during relapses. However, data regarding primary progressive (PP) MS is scarce. Objectives: To determine both the pro and active forms of MMP-9 in PPMS and transitional progressive (TP) MS, RRMS and healthy controls (HC), and to assess the relationship between MMP-9 levels and clinical and radiological variables in PP/TPMS. Methods: 73 patients with PP/TPMS, 50 RRMS and 43 HC were studied. Levels of pro and active forms of MMP-9 in serum were measured with ELISA. EDSS and MSFC scores were recorded and T2- and T1-weighted MR scans were obtained at the time of blood sampling and one and two years later for PP/TP MS cases. Results: MMP-9 levels were 202.27 ng/ml for PP/TPMS, 242.20 ng/ml for RRMS and 274.49 ng/ml for HC. MMP-9 levels were significantly lower in PP/TPMS compared to RRMS(P-0.026) and HC (P- 0.001). No significant correlations were found between MMP-9 levels and clinical scores or radiological parameters. Conclusions: These results point to different regulatory mechanisms of MMP-9 production and/or activity between PP/TPMS and RRMS.

Key Words: blood-brain barrier • MMP-9 • multiple sclerosis • primary progressive

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