|
Sign In to gain access to subscriptions and/or personal tools.
|
Progressive grey matter atrophy in clinically early relapsing-remitting multiple sclerosis
D T Chard
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
C M Griffin
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
W Rashid
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
G R Davies
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
D R Altmann
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
R Kapoor
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
G J Barker
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK, Neuroimaging Research Group, Institute of Psychiatry, Kings College London, De Crespigny Park, London SE5 8AF, UK
A J Thompson
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
D H Miller
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK, d.miller{at}ion.ucl.ac.uk
Brain atrophy appears to occur in patients with multiple sclerosis (MS) in excess of that associated with normal ageing, and may be observed early in the clinical course of the disease. The dynamics and tissue specificity of this process remain unclear. This preliminary study explored the evolution of brain grey matter (GM) and white matter (WM) volume loss (as fractions of total intracranial volumes) in 13 subjects with relapsing-remitting MS (mean disease duration 1.9 years at first scan), compared with nine normal control (NC) subjects. Subjects were scanned every six months for 18 months. In MS compared with NC subjects, significant differences in WM fractional volumes were observed at baseline (mean-5.8%, P/0.008) but no apparent progressive WM tissue loss was detected. In contrast, while no significant differences in GM fractional volumes were observed at baseline, there was significantly greater time-related volume loss in MS compared with NC subjects over the follow-up period (circa-0.0086 per year in MS subjects,-0.0021 per year in the NC subjects, difference 0.010). These results suggest that while both GM and WM atrophy are seen early in the clinical course of MS, they may not occur concurrently and may evolve at different rates.
Key Words: brain atrophy • lesion load • longitudinal • MRI • multiple sclerosis
Multiple Sclerosis, Vol. 10, No. 4,
387-391 (2004)
DOI: 10.1191/1352458504ms1050oa
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
B Healy, P Valsasina, M Filippi, and R Bakshi
Sample size requirements for treatment effects using gray matter, white matter and whole brain volume in relapsing-remitting multiple sclerosis
J. Neurol. Neurosurg. Psychiatry,
November 1, 2009;
80(11):
1218 - 1224.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. van der Walt, J. Stankovich, M. Bahlo, B. V. Taylor, I.A.F. van der Mei, S. J. Foote, T. J. Kilpatrick, J. P. Rubio, and H. Butzkueven
Apolipoprotein genotype does not influence MS severity, cognition, or brain atrophy
Neurology,
September 29, 2009;
73(13):
1018 - 1025.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J Furby, T Hayton, D Altmann, R Brenner, J Chataway, K. Smith, D. Miller, and R Kapoor
Different white matter lesion characteristics correlate with distinct grey matter abnormalities on magnetic resonance imaging in secondary progressive multiple sclerosis
Multiple Sclerosis,
June 1, 2009;
15(6):
687 - 694.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G Tedeschi, D Dinacci, M Comerci, L Lavorgna, G Savettieri, A Quattrone, P Livrea, F Patti, V Brescia Morra, G Servillo, et al.
Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study
Multiple Sclerosis,
February 1, 2009;
15(2):
204 - 211.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R G Henry, M Shieh, D T Okuda, A Evangelista, M L Gorno-Tempini, and D Pelletier
Regional grey matter atrophy in clinically isolated syndromes at presentation
J. Neurol. Neurosurg. Psychiatry,
November 1, 2008;
79(11):
1236 - 1244.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J Furby, T Hayton, V Anderson, D Altmann, R Brenner, J Chataway, R. Hughes, K. Smith, D. Miller, and R Kapoor
Magnetic resonance imaging measures of brain and spinal cord atrophy correlate with clinical impairment in secondary progressive multiple sclerosis
Multiple Sclerosis,
September 1, 2008;
14(8):
1068 - 1075.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Mesaros, M. A. Rocca, M. Absinta, A. Ghezzi, N. Milani, L. Moiola, P. Veggiotti, G. Comi, and M. Filippi
Evidence of thalamic gray matter loss in pediatric multiple sclerosis
Neurology,
March 25, 2008;
70(13_Part_2):
1107 - 1112.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Summers, L. Fisniku, V. Anderson, D. Miller, L. Cipolotti, and M. Ron
Cognitive impairment in relapsing--remitting multiple sclerosis can be predicted by imaging performed several years earlier
Multiple Sclerosis,
March 1, 2008;
14(2):
197 - 204.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Calabrese, N. De Stefano, M. Atzori, V. Bernardi, I. Mattisi, L. Barachino, A. Morra, L. Rinaldi, C. Romualdi, P. Perini, et al.
Detection of Cortical Inflammatory Lesions by Double Inversion Recovery Magnetic Resonance Imaging in Patients With Multiple Sclerosis
Arch Neurol,
October 1, 2007;
64(10):
1416 - 1422.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Audoin, G. Davies, W. Rashid, L. Fisniku, A.J. Thompson, and D.H. Miller
Voxel-based analysis of grey matter magnetization transfer ratio maps in early relapsing remitting multiple sclerosis
Multiple Sclerosis,
May 1, 2007;
13(4):
483 - 489.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G R Davies, A Hadjiprocopis, D R Altmann, D T Chard, C M Griffin, W Rashid, G J Parker, P S Tofts, R Kapoor, A J Thompson, et al.
Normal-appearing grey and white matter T1 abnormality in early relapsing-remitting multiple sclerosis: a longitudinal study
Multiple Sclerosis,
March 1, 2007;
13(2):
169 - 177.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B Audoin, D Ibarrola, I Malikova, E Soulier, S Confort-Gouny, M-V A. Duong, F Reuter, P Viout, A Ali-Cherif, P J Cozzone, et al.
Onset and underpinnings of white matter atrophy at the very early stage of multiple sclerosis - a two-year longitudinal MRI/MRSI study of corpus callosum
Multiple Sclerosis,
January 1, 2007;
13(1):
41 - 51.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J H Simon
Brain atrophy in multiple sclerosis: what we know and would like to know
Multiple Sclerosis,
November 1, 2006;
12(6):
679 - 687.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Oreja-Guevara, A. Charil, D. Caputo, R. Cavarretta, M. P. Sormani, and M. Filippi
Magnetization transfer magnetic resonance imaging and clinical changes in patients with relapsing-remitting multiple sclerosis.
Arch Neurol,
May 1, 2006;
63(5):
736 - 740.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W Rashid, G R Davies, D T Chard, C M Griffin, D R Altmann, R Gordon, A J Thompson, and D H Miller
Increasing cord atrophy in early relapsing-remitting multiple sclerosis: a 3 year study
J. Neurol. Neurosurg. Psychiatry,
January 1, 2006;
77(1):
51 - 55.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Valsasina, B. Benedetti, M. Rovaris, M. P. Sormani, G. Comi, and M. Filippi
Evidence for progressive gray matter loss in patients with relapsing-remitting MS
Neurology,
October 11, 2005;
65(7):
1126 - 1128.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Sastre-Garriga, G. T. Ingle, D. T. Chard, M. Cercignani, L. Ramio-Torrenta, D. H. Miller, and A. J. Thompson
Grey and white matter volume changes in early primary progressive multiple sclerosis: a longitudinal study
Brain,
June 1, 2005;
128(6):
1454 - 1460.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Tiberio, D. T. Chard, D. R. Altmann, G. Davies, C. M. Griffin, W. Rashid, J. Sastre-Garriga, A. J. Thompson, and D. H. Miller
Gray and white matter volume changes in early RRMS: A 2-year longitudinal study
Neurology,
March 22, 2005;
64(6):
1001 - 1007.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
