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RANTES: a genetic risk marker for multiple sclerosis

Genetic Research Institute of the Desert, Eisenhower Medical Center, Probst # 308, 39000 Bob Hope Dr, Rancho Mirage, CA, USA

David E Comings

Carlsbad Science Foundation, Monrovia, CA 91016, USA

James MacMurray

Carlsbad Science Foundation, Monrovia, CA 91016, USA

Ravi K Vuthoori

Genetic Research Institute of the Desert, Eisenhower Medical Center, Probst # 308, 39000 Bob Hope Dr, Rancho Mirage, CA, USA

Wallace W Tourtellotte

Neurology and Research Services, VA, West Los Angeles Healthcare Center and Department of Neurology, UCLA, CA, USA

Rashed M Nagra

Neurology and Research Services, VA, West Los Angeles Healthcare Center and Department of Neurology, UCLA, CA, USA

Lawrence A Cone

Genetic Research Institute of the Desert, Eisenhower Medical Center, Probst # 308, 39000 Bob Hope Dr, Rancho Mirage, CA, USA, Sections of Immunology and Infectious Diseases, Eisenhower Medical Center, Rancho Mirage, CA, USA, randavolu{at}gridonline.org

Regulated upon activation, normal T-cell expressed and secreted (RANTES) is a beta-chemokine and has been detected in brain lesions of multiple sclerosis (MS) patients. Considering its potential role in MS, we screened two functional polymorphisms in the proximal promoter region of the RANTES in MS patients versus controls. Methods: We examined 140 postmortem brain samples from subjects with a primary diagnosis of MS, and peripheral blood samples from 216 control subjects. The RANTES-28C/G and -403G/A promoter polymorphisms were examined. All subjects were non-Hispanic Caucasians. Results: MS cases differed from controls showing a significant association with the 403G/A polymorphism (odds ratio, 2.359, [1.465-3.799]; P-0.0001), but not the -28C/G (P-NS) polymorphism. There was a significant association of the -28G allele with both early onset (P-0.031) and longer survival (P-0.006). Conclusion: There is a significant but complex association of the RANTES gene with MS.

Key Words: central nervous system • chemokines • cytokines • multiple sclerosis • RANTES

Multiple Sclerosis, Vol. 10, No. 5, 536-539 (2004)
DOI: 10.1191/1352458504ms1080oa


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