This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Hoogervorst, E L. Articles by Uitdehaag, B M. Search for Related Content PubMed PubMed Citation Articles by Hoogervorst, E L. Articles by Uitdehaag, B M. Social Bookmarking                         What's this?

Multiple Sclerosis Impact Scale (MSIS-29): relation to established measures of impairment and disability

Department of Neurology, VU Medical Center, Amsterdam, The Netherlands, e.hoogervorst{at}vumc.nl

J NP Zwemmer

Department of Neurology, VU Medical Center, Amsterdam, The Netherlands

B Jelles

Department of Neurology, VU Medical Center, Amsterdam, The Netherlands

C H Polman

Department of Neurology, VU Medical Center, Amsterdam, The Netherlands

B MJ Uitdehaag

Department of Neurology, VU Medical Center, Amsterdam, The Netherlands, Department of Clinical Epidemiology and Biostatistics, VU Medical Center, Amsterdam, The Netherlands

Objective: To validate the newly developed Multiple Sclerosis Impact Scale (MSIS-29) in a large, well characterized, independent group of MS patients by investigating the relation between the MSIS-29 and the Guy’s Neurological Disability Scale (GNDS), the Expanded Disability Status Scale (EDSS) and the MS Functional Composite (MSFC). Methods: Two hundred MS patients were recruited at our outpatient department. At the same visit GNDS, EDSS, MSFC and MSIS-29 were assessed. Data obtained from GNDS, EDSS and MSFC assessment were compared to both physical and psychological impact scores of the MSIS-29. In addition the contribution of GNDS subcategories, EDSS functional systems and MSFC components to the physical and psychological impact scores of the MSIS-29 was studied. Results: Median scores were 37.5 for the physical and 22.2 for the psychological impact score of the MSIS-29, 13.0 for GNDS and 4.0 for EDSS. Mean MSFC was 0.07. The physical impact score showed good correlations with both GNDS (0.79) and EDSS (0.68) and a moderate correlation with the MSFC (- 0.53). The psychological impact score showed weak correlations with EDSS (0.22) and MSFC (-0.30) and a moderately strong correlation with the GNDS (0.58). In 50 (25%) patients, scores on physical and psychological impact scales diverted, i.e., a relative high score on one scale combined with a relative low score on the other scale. This was related to the clinical disease course. Conclusion: Our study supports the use of the MSIS-29 as a measure for the assessment of physical impact of MS on normal daily life. In addition, our data provides a deeper understanding of the factors that determine both physical and psychological disease impact. Discrepancies between the latter two aspects deserve further attention.

Key Words: disability • MS • MSIS-29 • validation

Multiple Sclerosis, Vol. 10, No. 5, 569-574 (2004)
DOI: 10.1191/1352458504ms1078oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				O. Gray, G. McDonnell, and S. Hawkins Tried and tested: the psychometric properties of the multiple sclerosis impact scale (MSIS-29) in a population-based study Multiple Sclerosis, January 1, 2009; 15(1): 75 - 80. [Abstract] [PDF]

				L. Costelloe, K. O'Rourke, C. McGuigan, C. Walsh, N. Tubridy, and M. Hutchinson The longitudinal relationship between the patient-reported Multiple Sclerosis Impact Scale and the clinician-assessed Multiple Sclerosis Functional Composite Multiple Sclerosis, March 1, 2008; 14(2): 255 - 258. [Abstract] [PDF]

				L. Costelloe, K. O'Rourke, H. Kearney, C. McGuigan, L. Gribbin, M. Duggan, L. Daly, N. Tubridy, and M. Hutchinson The patient knows best: significant change in the physical component of the Multiple Sclerosis Impact Scale (MSIS-29 physical) J. Neurol. Neurosurg. Psychiatry, August 1, 2007; 78(8): 841 - 844. [Abstract] [Full Text] [PDF]

				V. de Groot, H. Beckerman, B. M. J. Uitdehaag, H. C. W. de Vet, G. J. Lankhorst, C. H. Polman, and L. M. Bouter The usefulness of evaluative outcome measures in patients with multiple sclerosis Brain, October 1, 2006; 129(10): 2648 - 2659. [Abstract] [Full Text] [PDF]

				J C Hobart, A Riazi, D L Lamping, R Fitzpatrick, and A J Thompson How responsive is the Multiple Sclerosis Impact Scale (MSIS-29)? A comparison with some other self report scales J. Neurol. Neurosurg. Psychiatry, November 1, 2005; 76(11): 1539 - 1543. [Abstract] [Full Text] [PDF]

				C. Heffernan and C. Jenkinson Review Paper: Measuring outcomes for neurological disorders: a review of disease-specific health status instruments for three degenerative neurological conditions Chronic Illness, June 1, 2005; 1(2): 131 - 142. [Abstract] [PDF]