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Multiple Sclerosis, Vol. 10, No. 5, 596-597 (2004)
DOI: 10.1191/1352458504ms1079sr

Intravenous corticosteroids in the postpartum period for reduction of acute exacerbations in multiple sclerosis

J de Seze

Department of Neurology, Hôpital R. Salengro, CHRU of Lille, Lille, France, j-deseze{at}chru-lille.fr

M Chapelotte

Department of Neurology, Hôpital R. Salengro, CHRU of Lille, Lille, France

S Delalande

Department of Neurology, Hôpital R. Salengro, CHRU of Lille, Lille, France

D Ferriby

Department of Neurology, Hôpital R. Salengro, CHRU of Lille, Lille, France

T Stojkovic

Department of Neurology, Hôpital R. Salengro, CHRU of Lille, Lille, France

P Vermersch

Department of Neurology, Hôpital R. Salengro, CHRU of Lille, Lille, France

In order to assess the effectiveness of monthly intravenous corticosteroids in reducing childbirth-associated acute exacerbations in multiple sclerosis (MS), we compared pregnant patients followed up in our MS clinic. During the first period (1996-1998), 22 patients did not receive any treatment after delivery. During the second period (1999-2001), following the publication of the PRIMS study, 20 patients were treated monthly with 1 g of intravenous corticosteroids during the six months of the postpartum period. In both groups the relapse rate increased during the first trimester postpartum but it was higher in the untreated group (2±0.66 [mean±SD]) compared with the treated group (0.8±0.41) (P=0.018), suggesting a beneficial effect of monthly intravenous corticosteroids.

Key Words: corticosteroid • multiple sclerosis • postpartum • pregnancy • relapses


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