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Waldenström's macroglobulinemia developing in a patient with multiple sclerosis: coincidence or association?

First Department of Internal Medicine, University of Athens Medical School, ‘Laiko’ Hospital, Athens, Greece, deftereo{at}otenet.gr

D Farmakis

First Department of Internal Medicine, University of Athens Medical School, ‘Laiko’ Hospital, Athens, Greece

A Papadogianni

First Department of Internal Medicine, University of Athens Medical School, ‘Laiko’ Hospital, Athens, Greece

B Besleme

First Department of Internal Medicine, University of Athens Medical School, ‘Laiko’ Hospital, Athens, Greece

E Diamanti-Kandarakis

First Department of Internal Medicine, University of Athens Medical School, ‘Laiko’ Hospital, Athens, Greece

E Polymeropoylos

First Department of Internal Medicine, University of Athens Medical School, ‘Laiko’ Hospital, Athens, Greece

D Georgonikou

First Department of Internal Medicine, University of Athens Medical School, ‘Laiko’ Hospital, Athens, Greece

A Aessopos

First Department of Internal Medicine, University of Athens Medical School, ‘Laiko’ Hospital, Athens, Greece

Multiple sclerosis (MS) has been reported in association with haematological abnormalities, including monoclonal gammopathies. We present a 54-year-old male patient with a 30-year history of MS who was admitted to our hospital for investigation of anaemia and increased erythrocyte sedimentation rate. A monoclonal IgM protein was detected by serum protein immunofixation, while bone marrow biopsy indicated a 70% infiltration by small lymphoplasmacytoid cells, in the context of a lymphoplasmacytoid immunocytoma, findings compatible to the diagnosis of Waldenström's macroglobulinemia (WM). To our knowledge, this is the first report of WM in a patient with MS. Further to the coexistence of the two diseases observed in the case presented here, there is additional evidence suggesting that the association of MS with plasma cell dyscrasias may not be coincidental.

Key Words: utoimmune diseases • demyelinating diseases • monoclonal gammopathies • multiple sclerosis • plasma cell dyscrasias • Waldenström's macroglobulinemia

Multiple Sclerosis, Vol. 10, No. 5, 598-600 (2004)
DOI: 10.1191/1352458504ms1091cr


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