This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by GR, D. Articles by DH, M. Search for Related Content PubMed PubMed Citation Articles by GR, D. Articles by DH, M. Social Bookmarking                   What's this?

Estimation of the macromolecular proton fraction and bound pool T2 in multiple sclerosis

NMR Research Unit, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK

Tozer DJ

NMR Research Unit, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK

Cercignani M

NMR Research Unit, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK

Ramani A

NMR Research Unit, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK

Dalton CM

NMR Research Unit, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK

Thompson AJ

NMR Research Unit, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK

Barker GJ

NMR Research Unit, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK, Neuroimaging Research Group, Box 042, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK

Tofts PS

NMR Research Unit, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK

Miller DH

NMR Research Unit, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK, d.miller{at}ion.ucl.ac.uk

This study used a model for magnetization transfer (MT) to estimate two underlying parameters: the macromolecular proton fraction (f) and the bound pool T₂ (T_2b) in patients with multiple sclerosis (MS). Sixty patients with clinically definite MS and 27 healthy controls were imaged using: (1) a dual echo fast spin echo sequence, (2) a MT sequence (with ten MT power and offset frequency combinations) and (3) proton density and T₁ weighted sequences (for T₁ relaxation time estimation). Fourteen normal-appearing white matter (NAWM) regions of interest (ROI) and six normal-appearing gray matter (NAGM) ROIs were outlined in all subjects. Lesions were also contoured in subjects affected by MS. The model was fitted to the data leading to estimates of T_2b and f. Results showed that T_2b was increased in lesions whereas f was reduced. In NAWM, f was decreased while T_2b was only increased in secondary progressive MS. NAWM f correlated modestly with disability. Further studies are needed to investigate the pathological basis of the abnormalities observed.

Key Words: magnetization transfer ratio • multiple sclerosis • normal appearing white matter • gray matter • lesions • myelin

Multiple Sclerosis, Vol. 10, No. 6, 607-613 (2004)
DOI: 10.1191/1352458504ms1105oa


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				B. H. Ridha, D. J. Tozer, M. R. Symms, K. C. Stockton, E. B. Lewis, M. M. Siddique, D. G. MacManus, M. N. Rossor, N. C. Fox, and P. S. Tofts Quantitative Magnetization Transfer Imaging in Alzheimer Disease Radiology, September 1, 2007; 244(3): 832 - 837. [Abstract] [Full Text] [PDF]