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Multiple Sclerosis
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Genetic analysis of SLC11A1 polymorphisms in multiple sclerosis patients

Manuel Comabella

Department of Neurology, Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d’Hebron (HUVH), Barcelona, Spain, mcomabel{at}vhebron.net

Laura Altet

Department of Animal and Food Sciences, Facultat de Veterinaria, Universitat Auto`noma de Barcelona, Bellaterra, Spain

Francesc Peris

Department of Statistics, Almirall Prodesfarma, Barcelona, Spain

Pablo Villoslada

Department of Neurology, Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d’Hebron (HUVH), Barcelona, Spain

Armand Sánchez

Department of Animal and Food Sciences, Facultat de Veterinaria, Universitat Auto`noma de Barcelona, Bellaterra, Spain

Xavier Montalban

Department of Neurology, Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d’Hebron (HUVH), Barcelona, Spain

Solute carrier 11a1 (SLC11A1; formerly NRAMP1, where NRAMP stands for natural resistance-associated macrophage protein) is a proton/bivalent cation antiporter that localizes to late endosomes/lysosomes. SLC11A1 regulates macrophage functions that are of potential importance in the induction and/or maintenance of autoimmune diseases such as rheumatoid arthritis, type 1 diabetes and Crohn’s disease. We investigated SLC11A1 gene as a candidate gene for genetic susceptibility to multiple sclerosis (MS) in our population. Four SLC11A1 gene polymorphisms (5?GT repeat, D543N, 1729 -55del4 and 1729 -271del4) were analysed in a case-control study of 195 patients with MS and 125 control subjects. We found no evidence of association between SLC11A1 polymorphisms and MS susceptibility in the Spanish population.

Key Words: association studies • autoimmune diseases • candidate genes • genetic susceptibility • multiple sclerosis • polymorphisms

Multiple Sclerosis, Vol. 10, No. 6, 618-620 (2004)
DOI: 10.1191/1352458504ms1097oa
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