This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by White, L J Articles by Vandenborne, K Search for Related Content PubMed PubMed Citation Articles by White, L J Articles by Vandenborne, K Pubmed/NCBI databases Medline Plus Health Information Exercise for Children Exercise and Physical Fitness Multiple Sclerosis Social Bookmarking                         What's this?

Resistance training improves strength and functional capacity in persons with multiple sclerosis

Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA, Applied Human Physiology Laboratory, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA, lwhite{at}hhp.ufl.edu

S C McCoy

Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA, Applied Human Physiology Laboratory, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA

V Castellano

Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA, Applied Human Physiology Laboratory, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA

G Gutierrez

Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA

J E Stevens

Department of Physical Therapy, University of Florida, Gainesville, FL 32611, USA

G A Walter

Department of Physiology, University of Florida, Gainesville, FL 32611, USA

K Vandenborne

Department of Physical Therapy, University of Florida, Gainesville, FL 32611, USA

The purpose of this study was to evaluate the effect of an eight-week progressive resistance training programme on lower extremity strength, ambulatory function, fatigue and self-reported disability in multiple sclerosis (MS) patients (mean disability score 3.79-0.8). Eight MS subjects volunteered for twice weekly training sessions. During the first two weeks, subjects completed one set of 8 -10 reps at 50% of maximal voluntary contraction (MVC) of knee flexion, knee extension and plantarflexion exercises. In subsequent sessions, the subjects completed one set of 10 -15 repetitions at 70% of MVC. The resistance was increased by 2 -5% when subjects completed 15 repetitions in consecutive sessions. Isometric strength of the quadriceps, hamstring, plantarflexor and dorsiflexor muscle groups was assessed before and after the training programme using an isokinetic dynamometer. Magnetic resonance images of the thigh were acquired before and after the exercise programme as were walking speed (25-ft), number of steps in 3 min, and self-reported fatigue and disability. Knee extension (7.4%), plantarflexion (52%) and stepping performance (8.7%) increased significantly (PB-0.05). Self-reported fatigue decreased (PB-0.05) and disability tended to decrease (P -0.07) following the training programme. MS patients are capable of making positive adaptations to resistance training that are associated with improved ambulation and decreased fatigue.

Key Words: disability • exercise • fatigue • fitness • multiple sclerosis • skeletal muscle • strength training

Multiple Sclerosis, Vol. 10, No. 6, 668-674 (2004)
DOI: 10.1191/1352458504ms1088oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				U. Dalgas, E. Stenager, J. Jakobsen, T. Petersen, H. J. Hansen, C. Knudsen, K. Overgaard, and T. Ingemann-Hansen Resistance training improves muscle strength and functional capacity in multiple sclerosis Neurology, November 3, 2009; 73(18): 1478 - 1484. [Abstract] [Full Text] [PDF]

				E. M. Snook and R. W. Motl Effect of Exercise Training on Walking Mobility in Multiple Sclerosis: A Meta-Analysis Neurorehabil Neural Repair, February 1, 2009; 23(2): 108 - 116. [Abstract] [PDF]

				U. Dalgas, E. Stenager, and T. Ingemann-Hansen Review: Multiple sclerosis and physical exercise: recommendations for the application of resistance-, endurance- and combined training Multiple Sclerosis, January 1, 2008; 14(1): 35 - 53. [Abstract] [PDF]

				R.W. Motl and J.L. Gosney Effect of exercise training on quality of life in multiple sclerosis: a meta-analysis Multiple Sclerosis, January 1, 2008; 14(1): 129 - 135. [Abstract] [PDF]

				A. Rampello and A. Chetta Author Response Physical Therapy, May 1, 2007; 87(5): 558 - 559. [Full Text] [PDF]

				B. Giesser, J. Beres-Jones, A. Budovitch, E. Herlihy, and S. Harkema Locomotor training using body weight support on a treadmill improves mobility in persons with multiple sclerosis: a pilot study Multiple Sclerosis, March 1, 2007; 13(2): 224 - 231. [Abstract] [PDF]

				P. F. Jenkins The Multiple Facets of Multiple Sclerosis Amer. Orthoptic Jrnl., January 1, 2007; 57(1): 69 - 78. [Abstract] [PDF]

				G L. Onambele and H Degens Improvements in muscle-tendon properties are beneficial to balance in multiple sclerosis Multiple Sclerosis, September 1, 2006; 12(5): 666 - 669. [Abstract] [PDF]

				G M Ramdharry, J F Marsden, B L Day, and A J Thompson De-stabilizing and training effects of foot orthoses in multiple sclerosis Multiple Sclerosis, April 1, 2006; 12(2): 219 - 226. [Abstract] [PDF]