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Pattern of neuropsychological impairment in the early phase of relapsing-remitting multiple sclerosis

Facultad de Psicología, Universidad de La Laguna, La Laguna 38205, Tenerife, Islas Canarias, Spain

A Nieto

Facultad de Psicología, Universidad de La Laguna, La Laguna 38205, Tenerife, Islas Canarias, Spain

M P Sánchez

Facultad de Psicología, Universidad de La Laguna, La Laguna 38205, Tenerife, Islas Canarias, Spain

T Wollmann

Facultad de Psicología, Universidad de La Laguna, La Laguna 38205, Tenerife, Islas Canarias, Spain

M A Hernández

Secciónde Neurología, Hospital Ntra. Sra. de Candelaria, La Laguna 38205, Tenerife, Islas Canarias, Spain

J Barroso

Facultad de Psicología, Universidad de La Laguna, La Laguna 38205, Tenerife, Islas Canarias, Spain, jbarroso{at}ull.es

To investigate the neuropsychological profile in the first few years post-onset of relapsing-remitting multiple sclerosis (MS) we carried out a comprehensive neuropsychological evaluation of 33 patients characterized by very short evolution of this disease, minimal levels of neurological disability and preserved general cognition. Thirty-three individually pair-matched controls were also evaluated. Patients performed as well as controls on many of the cognitive exploration measures. Nevertheless, the group of patients evinced a general slowness that affected motor execution and cognitive processing. Memory functions were characterized by preservation of working memory, retrieval or storage of information and a deficit at the acquisition phase in (verbal and visual) supraspan tasks. In addition, significant correlations were observed between some measures of information processing speed and memory. These results highlight the importance of studying cognitive deficits not only in the different subtypes of MS but also in different phases of the disease.

Key Words: attention • learning • memory • multiple sclerosis • neuropsychological assessment • neuropsychology • processing speed

Multiple Sclerosis, Vol. 11, No. 2, 191-197 (2005)
DOI: 10.1191/1352458505ms1139oa


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