SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Multiple Sclerosis
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Uitdehaag, B. M.
Right arrow Articles by Polman, C. H
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Uitdehaag, B. M.
Right arrow Articles by Polman, C. H
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Discrepancies in the interpretation of clinical symptoms and signs in the diagnosis of multiple sclerosis. A proposal for standardization

Bernard MJ Uitdehaag

Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands, bmj.uitdehaag{at}vumc.nl

Ludwig Kappos

Department of Neurology, Kantonsspital Basel Universitätskliniken, Basel, Switzerland

Lars Bauer

Schering AG, Berlin, Germany

Mark S Freedman

Multiple Sclerosis Research Clinic, The Ottawa Hospital, Ontario, Canada

David Miller

NMR Research Unit, Institute of Neurology and National Hospital for Neurology & Neurosurgery, London, UK

Rupert Sandbrink

Schering AG, Berlin, Germany

Chris H Polman

Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands

The new McDonald diagnostic criteria for multiple sclerosis (MS) incorporate detailed criteria for the interpretation and classification of magnetic resonance imaging (MRI) findings, but, in contrast, provide no instructions for the interpretation of clinical findings. Because MS according to the McDonald criteria is one of the primary endpoints in a large trial enrolling patients after the first manifestation suggestive for a demyelinating disease (BENEFIT study), it was decided to organize a centralized eligibility assessment for this trial. During this eligibility assessment it was observed that there were marked inconsistencies in the decisions of participating neurologists with respect to the classification of clinical symptoms as being caused by one or more lesions provoking discussions in about one in every five patients. This paper describes these inconsistencies and their sources, and recommends a systematic approach that attempts to reduce the variability in interpreting clinical findings.

Key Words: diagnosis • symptoms and signs

Multiple Sclerosis, Vol. 11, No. 2, 227-231 (2005)
DOI: 10.1191/1352458505ms1149oa
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Arch NeurolHome page
B. Moraal, C. Pohl, B. M. J. Uitdehaag, C. H. Polman, G. Edan, M. S. Freedman, H.-P. Hartung, L. Kappos, D. H. Miller, X. Montalban, et al.
Magnetic Resonance Imaging Predictors of Conversion to Multiple Sclerosis in the BENEFIT Study
Arch Neurol, November 1, 2009; 66(11): 1345 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
O. Garcea, A. Villa, F. Caceres, T. Adoni, M. Alegria, R. Barbosa Thomaz, R. Buzo, L. Llamas Lopez, and M. Rivera Kindel
Early treatment of multiple sclerosis: a Latin American Experts Meeting
Multiple Sclerosis, October 1, 2009; 15(3_suppl): S1 - S12.
[Abstract] [PDF]

Home page
 Mult SclerHome page
P O'Connor, R. Kinkel, and M Kremenchutzky
Efficacy of intramuscular interferon beta-1a in patients with clinically isolated syndrome: analysis of subgroups based on new risk criteria
Multiple Sclerosis, June 1, 2009; 15(6): 728 - 734.
[Abstract] [PDF]

Home page
 Mult SclerHome page
D. Miller, B. Weinshenker, M Filippi, B. Banwell, J. Cohen, M. Freedman, S. Galetta, M Hutchinson, R. Johnson, L Kappos, et al.
Differential diagnosis of suspected multiple sclerosis: a consensus approach
Multiple Sclerosis, November 1, 2008; 14(9): 1157 - 1174.
[Abstract] [PDF]

Home page
 Mult SclerHome page
J.M. Nielsen, B. Moraal, C.H. Polman, P. Poppe, M. de Vos, M.S. Freedman, L. Kappos, F. Barkhof, L. Bauer, C. Pohl, et al.
Classification of patients with a clinically isolated syndrome based on signs and symptoms is supported by magnetic resonance imaging results
Multiple Sclerosis, July 1, 2007; 13(6): 717 - 721.
[Abstract] [PDF]

Home page
 Mult SclerHome page
R. Pelayo, M. Tintore, A. Rovira, J. Rio, C. Nos, E. Grive, N. Tellez, M. Comabella, and X. Montalban
Polyregional and hemispheric syndromes: a study of these uncommon first attacks in a CIS cohort
Multiple Sclerosis, July 1, 2007; 13(6): 731 - 736.
[Abstract] [PDF]

Home page
 NeurologyHome page
L. Kappos, C. H. Polman, M. S. Freedman, G. Edan, H. P. Hartung, D. H. Miller, X. Montalban, F. Barkhof, L. Bauer, P. Jakobs, et al.
Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes
Neurology, October 10, 2006; 67(7): 1242 - 1249.
[Abstract] [Full Text] [PDF]


Advertisement