This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Soilu-Hänninen, M Articles by Hänninen, A Search for Related Content PubMed PubMed Citation Articles by Soilu-Hänninen, M Articles by Hänninen, A Social Bookmarking                         What's this?

25-Hydroxyvitamin D levels in serum at the onset of multiple sclerosis

Medicity Research Laboratory, Tykistö katu 6, FIN-20520 Turku, Finland, Department of Neurology, University of Turku, FIN-20521 Turku, Finland, mersoi{at}utu.fi

L Airas

Department of Neurology, University of Turku, FIN-20521 Turku, Finland

I Mononen

Turku University Hospital Central Laboratory, FIN-20521 Turku, Finland

A Heikkilä

Department of Neurology, University of Turku, FIN-20521 Turku, Finland

M Viljanen

Department of Medical Microbiology, University of Turku, FIN-20520 Turku, Finland

A Hänninen

Medicity Research Laboratory, Tykistö katu 6, FIN-20520 Turku, Finland, Department of Medical Microbiology, University of Turku, FIN-20520 Turku, Finland

Past sun exposure and vitamin D supplementation have been associated with a reduction in the risk of MS. We measured the serum concentration of 25-hydroxyvitamin D (25[OH]D) at the time of MS diagnosis in 40 MS patients and 40 controls. We found no difference in the serum levels of 25(OH)D between MS patients and controls when all samples or samples obtained during winter months were compared, but MS patients had significantly lower serum 25(OH)D concentrations in June to September than the controls. The vitamin D stores were adequate for bone metabolism (> 37 nmol/L) in 70% of MS patients throughout the year and within the hypovitaminosis level (< 37 nmol/L) in 30% of MS patients at some time of the year. During MS-relapses, 25(OH)D levels were lower than in remission, but mostly within the reference range observed in relation with normal bone metabolism. We conclude that the vitamin D stores in most MS patients are adequate for their normal bone metabolism. However, lower vitamin D levels during MS relapses than in remission suggest that vitamin D could be involved in the regulation of the clinical disease activity of MS. The optimal serum levels of vitamin D for the regulation of immune responses remain to be determined.

Key Words: EAE • environmental factors • MRI • multiple sclerosis • vitamin D

Multiple Sclerosis, Vol. 11, No. 3, 266-271 (2005)
DOI: 10.1191/1352458505ms1157oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				T. Kulie, A. Groff, J. Redmer, J. Hounshell, and S. Schrager Vitamin D: An Evidence-Based Review J Am Board Fam Med, November 1, 2009; 22(6): 698 - 706. [Abstract] [Full Text] [PDF]

				F. E. Nashold, K. M. Spach, J. A. Spanier, and C. E. Hayes Estrogen Controls Vitamin D3-Mediated Resistance to Experimental Autoimmune Encephalomyelitis by Controlling Vitamin D3 Metabolism and Receptor Expression J. Immunol., September 15, 2009; 183(6): 3672 - 3681. [Abstract] [Full Text] [PDF]

				J. L. Lapp Vitamin D: Bone Health and Beyond American Journal of Lifestyle Medicine, September 1, 2009; 3(5): 386 - 393. [Abstract] [PDF]

				J. Kragt, B. van Amerongen, J Killestein, C. Dijkstra, B. Uitdehaag, C. Polman, and P Lips Higher levels of 25-hydroxyvitamin D are associated with a lower incidence of multiple sclerosis only in women Multiple Sclerosis, January 1, 2009; 15(1): 9 - 15. [Abstract] [PDF]

				J Smolders, P Menheere, A Kessels, J Damoiseaux, and R Hupperts Association of vitamin D metabolite levels with relapse rate and disability in multiple sclerosis Multiple Sclerosis, November 1, 2008; 14(9): 1220 - 1224. [Abstract] [PDF]

				R. Bouillon, G. Carmeliet, L. Verlinden, E. van Etten, A. Verstuyf, H. F. Luderer, L. Lieben, C. Mathieu, and M. Demay Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice Endocr. Rev., October 1, 2008; 29(6): 726 - 776. [Abstract] [Full Text] [PDF]

				S.-M. Orton, A. P Morris, B. M Herrera, S. V Ramagopalan, M. R Lincoln, M. J Chao, R. Vieth, A D. Sadovnick, and G. C Ebers Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis Am. J. Clinical Nutrition, August 1, 2008; 88(2): 441 - 447. [Abstract] [Full Text] [PDF]

				M Soilu-Hanninen, M Laaksonen, I Laitinen, J-P Eralinna, E-M Lilius, and I Mononen A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis J. Neurol. Neurosurg. Psychiatry, February 1, 2008; 79(2): 152 - 157. [Abstract] [Full Text] [PDF]

				M.S. Barnes, M.P. Bonham, P.J. Robson, J.J. Strain, A.S. Lowe-Strong, J. Eaton-Evans, F. Ginty, and J.M.W. Wallace Assessment of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D3 concentrations in male and female multiple sclerosis patients and control volunteers Multiple Sclerosis, June 1, 2007; 13(5): 670 - 672. [Abstract] [PDF]

				S. J Brown The Role of Vitamin D in Multiple Sclerosis Ann. Pharmacother., June 1, 2006; 40(6): 1158 - 1161. [Abstract] [Full Text] [PDF]