This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Lim, E T Articles by Giovannoni, G Search for Related Content PubMed PubMed Citation Articles by Lim, E T Articles by Giovannoni, G Social Bookmarking                         What's this?

Anti-myelin antibodies do not allow earlier diagnosis of multiple sclerosis

Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

T Berger

Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria

M Reindl

Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria

C M Dalton

MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

K Fernando

MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

G Keir

Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

E J Thompson

Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

D H Miller

MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

G Giovannoni

Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK, G.Giovannoni{at}ion.ucl.ac.uk

This study investigates whether the presence of serum and plasma anti-myelin oligodendrocyte glycoprotein (MOG) and anti-myelin basic protein (MBP) in patients presenting with a clinically isolated syndrome compatible with demyelination (CIS) predicts early conversion to multiple sclerosis (MS). Forty-seven patients with CIS (46 with optic neuritis) had anti-MOG and anti-MBP antibodies analysed at baseline, and clinical and magnetic resonance imaging assessments. There was no evidence that the MS status based on either the McDonald or Poser criteria relates to the antibody status.

Key Words: anti-myelin antibodies • clinically isolated syndrome • multiple sclerosis

Multiple Sclerosis, Vol. 11, No. 4, 492-494 (2005)
DOI: 10.1191/1352458505ms1187sr


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M H J Vogt, C E Teunissen, E Iacobaeus, D A M Heijnen, E C W Breij, T Olsson, L Brundin, J Killestein, and C. D Dijkstra Cerebrospinal fluid anti-myelin antibodies are related to magnetic resonance measures of disease activity in multiple sclerosis J. Neurol. Neurosurg. Psychiatry, October 1, 2009; 80(10): 1110 - 1115. [Abstract] [Full Text] [PDF]

				H. Wang, K. L. Munger, M. Reindl, E. J. O'Reilly, L. I. Levin, T. Berger, and A. Ascherio Myelin oligodendrocyte glycoprotein antibodies and multiple sclerosis in healthy young adults Neurology, October 7, 2008; 71(15): 1142 - 1146. [Abstract] [Full Text] [PDF]

				C. Breithaupt, B. Schafer, H. Pellkofer, R. Huber, C. Linington, and U. Jacob Demyelinating Myelin Oligodendrocyte Glycoprotein-Specific Autoantibody Response Is Focused on One Dominant Conformational Epitope Region in Rodents J. Immunol., July 15, 2008; 181(2): 1255 - 1263. [Abstract] [Full Text] [PDF]

				S. Amor and G. Giovannoni Antibodies to myelin oligodendrocyte glycoprotein as a biomarker in multiple sclerosis are we there yet? Multiple Sclerosis, November 1, 2007; 13(9): 1083 - 1085. [PDF]

				V. Tomassini, L. De Giglio, M. Reindl, P. Russo, I. Pestalozza, P. Pantano, T. Berger, and C. Pozzilli Anti-myelin antibodies predict the clinical outcome after a first episode suggestive of MS Multiple Sclerosis, November 1, 2007; 13(9): 1086 - 1094. [Abstract] [PDF]

				J. Kuhle, C. Pohl, M. Mehling, G. Edan, M. S. Freedman, H.-P. Hartung, C. H. Polman, D. H. Miller, X. Montalban, F. Barkhof, et al. Lack of Association between Antimyelin Antibodies and Progression to Multiple Sclerosis N. Engl. J. Med., January 25, 2007; 356(4): 371 - 378. [Abstract] [Full Text] [PDF]

				R. Pelayo, M. Tintore, X. Montalban, A. Rovira, C. Espejo, M. Reindl, and T. Berger Antimyelin Antibodies with No Progression to Multiple Sclerosis N. Engl. J. Med., January 25, 2007; 356(4): 426 - 428. [Full Text] [PDF]

				S J Pittock, M Reindl, S Achenbach, T Berger, W Bruck, F Konig, Y Morales, H Lassmann, S Bryant, S B Moore, et al. Myelin oligodendrocyte glycoprotein antibodies in pathologically proven multiple sclerosis: frequency, stability and clinicopathologic correlations Multiple Sclerosis, January 1, 2007; 13(1): 7 - 16. [Abstract] [PDF]

				C H Polman and J Killestein Anti-myelin antibodies in multiple sclerosis: clinically useful? J. Neurol. Neurosurg. Psychiatry, June 1, 2006; 77(6): 712 - 712. [Full Text] [PDF]

				S Rauer, B Euler, M Reindl, and T Berger Antimyelin antibodies and the risk of relapse in patients with a primary demyelinating event. J. Neurol. Neurosurg. Psychiatry, June 1, 2006; 77(6): 739 - 742. [Abstract] [Full Text] [PDF]