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Anti-myelin antibodies do not allow earlier diagnosis of multiple sclerosis

Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

T Berger

Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria

M Reindl

Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria

C M Dalton

MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

K Fernando

MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

G Keir

Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

E J Thompson

Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

D H Miller

MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

G Giovannoni

Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK, G.Giovannoni{at}ion.ucl.ac.uk

This study investigates whether the presence of serum and plasma anti-myelin oligodendrocyte glycoprotein (MOG) and anti-myelin basic protein (MBP) in patients presenting with a clinically isolated syndrome compatible with demyelination (CIS) predicts early conversion to multiple sclerosis (MS). Forty-seven patients with CIS (46 with optic neuritis) had anti-MOG and anti-MBP antibodies analysed at baseline, and clinical and magnetic resonance imaging assessments. There was no evidence that the MS status based on either the McDonald or Poser criteria relates to the antibody status.

Key Words: anti-myelin antibodies • clinically isolated syndrome • multiple sclerosis

Multiple Sclerosis, Vol. 11, No. 4, 492-494 (2005)
DOI: 10.1191/1352458505ms1187sr


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