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Multiple Sclerosis
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Validation of the NARCOMS Registry: fatigue assessment

Ruth Ann Marrie

Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH, USA, marrier{at}ccf.org

Gary Cutter

Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA

Tuula Tyry

Division of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA

Olympia Hadjimichael

Department of Neurology, Yale University Medical School, New Haven, CT, USA

Denise Campagnolo

Division of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA

Timothy Vollmer

Division of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA

Participants in the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry report disability using Performance Scales (PS), which assess eight domains. We aimed to validate the PS fatigue subscale (PSF) using the Fatigue Severity Scale (FSS) and the Modified Fatigue Impact Scale (MFIS) as external criteria. We measured correlations between the PSF and age, disease duration and PS subscales to assess construct validity. The PSF correlated strongly with the MFIS (r=0.72, p<0.0001) and FSS (r=0.75, p<0.0001). Correlations between the PSF and age, disease duration were low, indicating divergent validity. Correlations between the PSF and spasticity, sensory and mobility PS scales were moderate, indicating convergent validity. The PSF has adequate criterion and construct validity in MS.

Key Words: fatigue • multiple sclerosis • registry • reliability • self-report • validity

Multiple Sclerosis, Vol. 11, No. 5, 583-584 (2005)
DOI: 10.1191/1352458505ms1216oa
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