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Multiple Sclerosis, Vol. 12, No. 1, 112-115 (2006)
DOI: 10.1191/135248506ms1268cr

Core hypothermia in multiple sclerosis: case report with magnetic resonance imaging localization of a thalamic lesion

R A Linker

Department of Neurology, Bereich Humanmedizin, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, D-37099 Goettingen, Germany, Insitute for Multiple Sclerosis Research, University of Goettingen and Gemeinnuetzige Hertie-Stiftung, Waldweg 33, D-37073 Goettingen, Germany, r.linker{at}med.uni-goettingen.de

A Mohr

Department of Neuroradiology, Bereich Humanmedizin, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, D-37099 Goettingen, Germany

L Cepek

Department of Neurology, Bereich Humanmedizin, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, D-37099 Goettingen, Germany

R Gold

Insitute for Multiple Sclerosis Research, University of Goettingen and Gemeinnuetzige Hertie-Stiftung, Waldweg 33, D-37073 Goettingen, Germany

H Prange

Department of Neurology, Bereich Humanmedizin, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, D-37099 Goettingen, Germany

Hypothermia is a rare condition in multiple sclerosis (MS). We report on a patient with a longstanding secondary progressive MS and six episodes of recurring hypothermia down to 29.98C with associated hypotension, bradycardia, coagulopathy and electrolyte dysequilibrium. Magnetic resonance imaging (MRI) demonstrated severe involvement of the corpus callosum with an associated lesion in the right posterior thalamus. These findings may link hypothermia in MS with callosal and associated thalamic pathology to Shapiro’s syndrome, where agenesis of the corpus callosum and associated abnormalities are related to episodic spontaneous hypothermia. In MS, hypothermic episodes may be triggered by preceding infections, as shown in the present case.

Key Words: CNS inflammation • coma • corpus callosum • temperature regulation


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J E Alty and H L Ford
Multi-system complications of hypothermia: a case of recurrent episodic hypothermia with a review of the pathophysiology of hypothermia
Postgrad. Med. J., June 1, 2008; 84(992): 282 - 286.
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