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Multiple Sclerosis, Vol. 12, No. 2, 204-208 (2006)
DOI: 10.1191/135248506ms1265oa
© 2006 SAGE Publications

Treatment of depression for patients with multiple sclerosis in neurology clinics

D C Mohr

University of California, Veterans Administration Medical Center, 4150 Clement St. (116-A), San Francisco, CA 94121, USA, dmohr{at}itsa.ucsf.edu

S L Hart

University of California, Veterans Administration Medical Center, 4150 Clement St. (116-A), San Francisco, CA 94121, USA

I Fonareva

University of California, Veterans Administration Medical Center, 4150 Clement St. (116-A), San Francisco, CA 94121, USA

E S Tasch

Kaiser Permanente Medical Care Group of Northern California, 900 Kiely Blvd., Main Bldg-3rd Floor, Santa Clara, CA 95051, USA

The objective of this study was to examine the adequacy of antidepressant pharmacotherapy in a sample of patients with multiple sclerosis (MS) treated by neurologists.

Methods MS patients under the care of neurologists were recruited from a large health maintenance organization. Major depressive disorder (MDD) was diagnosed using a structured telephone interview. Antidepressant treatment data were obtained from the HMO pharmacy database.

Results Study participants included 260 patients with MS treated by 35 neurologists. A total of 67 (25.8%) patients met the criteria for MDD. Among the patients with MDD, 65.6% received no antidepressant medication, 4.7% received subthreshold doses from their neurologists, 26.6% received doses at threshold, and 3.1% received doses exceeding threshold.

Discussion Depression was undertreated by the neurologists treating this sample of patients with comorbid MS and MDD. Potential solutions are discussed.

Key Words: adequacy of care • antidepressant medication • depression • major depressive disorder • multiple sclerosis


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