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Multiple Sclerosis
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Multiple sclerosis-associated retrovirus and optic neuritis

S Sotgiu

Institute of Clinical Neurology, University of Sassari, Viale San Pietro 10, 07100 Sassari, Italy, stefanos{at}uniss.it

G Arru

Institute of Clinical Neurology, University of Sassari, Viale San Pietro 10, 07100 Sassari, Italy

M Söderström

Department of Ophthalmology, Huddinge University Hospital, SE-1451 86 Stockholm, Sweden

G Mameli

Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy

C Serra

Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy

A Dolei

Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy

One prognostic factor for early multiple sclerosis (MS) patients to develop a definite MS may be the presence of the MS-associated retrovirus (MSRV) in the cerebrospinal fluid (CSF). We designed a specific study on a cohort of optic neuritis (ON) patients to evaluate the MSRV-dependent conversion to MS relative to the prediction conferred by magnetic resonance imaging (MRI) and CSF abnormalities. At follow-up, 33.3% MSRV+ and 0% MSRV– ON patients developed MS (P=0.03). The prediction value is lower than that given by CSF and MRI abnormalities (42.3%). This intriguing finding is discussed in the light of the abundant discrepancies observed in the MSRV literature.

Key Words: multiple sclerosis • optic neuritis • MSRV • prognosis • nested RT-PCR

Multiple Sclerosis, Vol. 12, No. 3, 357-359 (2006)
DOI: 10.1191/135248506ms1303sr
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This article has been cited by other articles:


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R Alvarez-Lafuente, M Garcia-Montojo, V De Las Heras, M. Dominguez-Mozo, M Bartolome, M. Benito-Martin, and R Arroyo
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G. Mameli, V. Astone, G. Arru, S. Marconi, L. Lovato, C. Serra, S. Sotgiu, B. Bonetti, and A. Dolei
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