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No association of CCR5D32 gene mutation with multiple sclerosis in Croatian and Slovenian patients

Smiljana Risti

Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Rijeka, Croatia, ristics{at}medri.hr

Luca Lovrei

Division of Medical Genetics, Department of Obstetrics and Gynecology, UMC, Ljubljana, Slovenia

Nada Starevi-izmarevi

Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Rijeka, Croatia

Bojana Brajenovi-Mili

Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Rijeka, Croatia

Saa ega Jazbec

Department of Neurology, UMC, Ljubljana, Slovenia

Vesna Barac-Latas

Department of Physiology and Immunology, School of Medicine, University of Rijeka, Rijeka, Croatia

Danilo Vejnovi

Department of Physiology and Immunology, School of Medicine, University of Rijeka, Rijeka, Croatia

Juraj Sepi

Postgraduate Study, School of Medicine, University of Rijeka, Rijeka, Croatia

Miljenko Kapovi

Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Rijeka, Croatia

Borut Peterlin

Division of Medical Genetics, Department of Obstetrics and Gynecology, UMC, Ljubljana, Slovenia

Several studies investigating the role of the CCR5D32 mutation in multiple sclerosis (MS) have reported varied, often contradictory results. Therefore in the present study we have analysed whether the CCR5D32 mutation is associated with the risk of/or disease process in Croatian and Slovene MS patients. Three hundred and twenty-five MS patients and 356 healthy controls were genotyped by the polymerase chain reaction method. Our results showed no significant differences in the distribution of CCR5D32 mutations between MS and control subjects, indicating that this mutation does not influence susceptibility to MS. Furthermore, we did not observe that CCR5D32 carrier-status could modulate age of disease onset or progression of the disease. It is therefore our conclusion that the present study indicates that the CCR5D32 mutation is neither protective of, nor a risk factor, for MS development.

Key Words: CCR5 polymorphism • multiple sclerosis • susceptibility gene

Multiple Sclerosis, Vol. 12, No. 3, 360-362 (2006)
DOI: 10.1191/135248506ms1305sr


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