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Multiple Sclerosis, Vol. 12, No. 4, 369-374 (2006)
DOI: 10.1191/1352458506ms1290oa

Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the common marmoset reflects the immunopathology of pattern II multiple sclerosis lesions

D Merkler

Department of Neuropathology, Georg-August University Göttingen, Göttingen, Germany

B Schmelting

Clinical Neurobiology Laboratory, German Primate Center, Göttingen, Germany

B Czéh

Clinical Neurobiology Laboratory, German Primate Center, Göttingen, Germany

E Fuchs

Clinical Neurobiology Laboratory, German Primate Center, Göttingen, Germany, Institut für Multiple-Sklerose-Forschung, Bereich Humanmedizin der Universität Göttingen und Gemeinnützige Hertie-Stiftung, Göttingen, Germany, Department of Neurology, Georg-August University Göttingen, Göttingen, Germany

C Stadelmann

Department of Neuropathology, Georg-August University Göttingen, Göttingen, Germany

W Brück

Department of Neuropathology, Georg-August University Göttingen, Göttingen, Germany, Institut für Multiple-Sklerose-Forschung, Bereich Humanmedizin der Universität Göttingen und Gemeinnützige Hertie-Stiftung, Göttingen, Germany, wbrueck{at}med.uni-goettingen.de

Pathomorphological studies described pathological heterogeneity in patients with multiple sclerosis (MS). Different effector mechanisms might therefore be responsible for lesion formation in MS. The present report shows that myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) in common marmoset monkeys reflects one specific lesional subtype of MS, namely MS pattern II lesions with antibody/complement-mediated damage. MOG-induced EAE in marmoset monkeys will, therefore, provide an ideal model for therapeutic approaches directed against B-cell/antibody/complement in MS.

Key Words: common marmoset • EAE • multiple sclerosis


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R. Diem, I. Demmer, S. Boretius, D. Merkler, B. Schmelting, S. K. Williams, M. B. Sattler, M. Bahr, T. Michaelis, J. Frahm, et al.
Autoimmune Optic Neuritis in the Common Marmoset Monkey: Comparison of Visual Evoked Potentials with MRI and Histopathology
Invest. Ophthalmol. Vis. Sci., August 1, 2008; 49(8): 3707 - 3714.
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