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Multiple Sclerosis
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CD24 V/V is an allele associated with the risk of developing multiple sclerosis in the Spanish population

D Otaegui

Unidad Experimental, Hospital Donostia, San Sebastián, Spain, uniexpe2{at}chdo.osakidetza.net

A Sáenz

Unidad Experimental, Hospital Donostia, San Sebastián, Spain

P Camaño

Unidad Experimental, Hospital Donostia, San Sebastián, Spain

L Blázquez

Unidad Experimental, Hospital Donostia, San Sebastián, Spain

M Goicoechea

Unidad Experimental, Hospital Donostia, San Sebastián, Spain

J Ruíz-Martínez

Servicio de Neurología, Hospital de Mendaro, Guipuzkoa, Spain

J Olaskoaga

Servicio de Neurología, Hospital Donostia, San Sebastián, Spain

J A Emparanza

Unidad de Epidemiología, Hospital Donostia, San Sebastián, Spain

A López de Munain

Servicio de Neurología, Hospital Donostia, San Sebastián, Spain

The allele C in the CD24 gene has been related to multiple sclerosis (MS). In this work we check this single nucleotide polymorphism (SNP) in a population of 135 patients and 285 controls. Our results confirm the association between the V/V genotype at aa 57 of this gene and MS and highlight the importance of taking into account the origin of the subjects to avoid a population bias.

Key Words: association • Basque • CD24 • multiple sclerosis • V/V

Multiple Sclerosis, Vol. 12, No. 4, 511-514 (2006)
DOI: 10.1191/135248506ms1314sr
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