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Multiple Sclerosis
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Periodic hyperthermia and abnormal circadian temperature rhythm in a patient with multiple sclerosis

J E Martinez-Rodriguez

Department of Neurology, Hospital del Mar, Institut Municipal d’Assistència Sanitària (IMAS), Institut Municipal d’Investigació Médica (IMIM), Universitat Autònoma de Barcelona, Barcelona, Spain

E Munteis

Department of Neurology, Hospital del Mar, Institut Municipal d’Assistència Sanitària (IMAS), Institut Municipal d’Investigació Médica (IMIM), Universitat Autònoma de Barcelona, Barcelona, Spain

J Roquer

Department of Neurology, Hospital del Mar, Institut Municipal d’Assistència Sanitària (IMAS), Institut Municipal d’Investigació Médica (IMIM), Universitat Autònoma de Barcelona, Barcelona, Spain, jroquer{at}imas.imim.es

Disturbances of the central thermoregulation in patients with multiple sclerosis (MS) are not often reported. We describe a 45-year old patient with a 13-year history of MS, who developed a clinical picture of recurrent hyperthermia. MRI showed a bilateral involvement of the hypothalamus in the setting of diffuse white matter disease. Serial body temperature measurement for five consecutive months disclosed an inversion of the circadian temperature rhythm. The clinical presentation and MRI findings suggested abnormalities of the central thermal control in relation to MS widespread involvement of the central nervous system (CNS).

Key Words: hyperthermia • hypothalamus • multiple sclerosis

Multiple Sclerosis, Vol. 12, No. 4, 515-517 (2006)
DOI: 10.1191/135248506ms1321cr
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