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Multiple Sclerosis
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The Face-Symbol Test and the Symbol-Digit Test are not reliable surrogates for the Paced Auditory Serial Addition Test in multiple sclerosis

J Williams

St. Vincent’s University Hospital, Elm Park, Dublin 4, Republic of Ireland

K O’Rourke

St. Vincent’s University Hospital, Elm Park, Dublin 4, Republic of Ireland

M Hutchinson

St. Vincent’s University Hospital, Elm Park, Dublin 4, Republic of Ireland

N Tubridy

St. Vincent’s University Hospital, Elm Park, Dublin 4, Republic of Ireland, n.tubridy{at}st-vincents.ie

The Paced Auditory Serial Addition Test (PASAT) is the chosen task for cognitive assessment in the multiple sclerosis functional composite (MSFC) and a widely used task in neuropsychological studies of people with multiple sclerosis (MS), but is unpopular with patients. The Face-Symbol Test (FST) and Symbol-Digit Tests (SDT) are alternative methods of cognitive testing in MS, which are easily administered and patient-friendly. In order to evaluate the potential of the FST as a possible surrogate for the PASAT, we directly compared the FST to the PASAT and the SDT in a cohort of 50 MS patients with varying levels of disability. There was significant correlation between SDT and FST scores (Spearman’s rho 0.80, 95% CI 0.66 - 0.88), R2 65%, with moderate inter-test agreement ({kappa} = 0.52). In contrast, SDT and FST scores were less predictive of PASAT scores. We concluded that neither the FST nor SDT are reliable surrogates for the PASAT.

Key Words: cognitive • Face-Symbol Test • multiple sclerosis • PASAT • Symbol-Digit Test

Multiple Sclerosis, Vol. 12, No. 5, 599-604 (2006)
DOI: 10.1177/1352458506070752


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This article has been cited by other articles:


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R. Grabner, F. Popotnig, S. Ropele, C. Neuper, F. Gorani, K. Petrovic, F. Ebner, S. Strasser-Fuchs, F. Fazekas, and C. Enzinger
Brain activation patterns elicited by the `Faces Symbol Test' -- a pilot fMRI study
Multiple Sclerosis, April 1, 2008; 14(3): 354 - 363.
[Abstract] [PDF]



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