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Cervical cord magnetization transfer ratio and clinical changes over 18 months in patients with relapsing-remitting multiple sclerosis: a preliminary study

Department of Neurology, Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy

D Caputo

MRI Research Group, Fondazione Don Gnocchi, Milan, Italy

R Cavarretta

MRI Research Group, Fondazione Don Gnocchi, Milan, Italy

M P Sormani

Department of Neurology, Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy

P Ferrante

MRI Research Group, Fondazione Don Gnocchi, Milan, Italy

M Filippi

Department of Neurology, Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy, MRI Research Group, Fondazione Don Gnocchi, Milan, Italy, filippi.massimo{at}hsr.it

Background Magnetization transfer ratio (MTR) permits the quantitative estimation of cervical cord tissue damage in patients with multiple sclerosis (MS).

Objective To determine whether a single time-point MTR scan of the cervical cord is associated with short-term disease evolution in patients with relapsing-remitting (RR) MS.

Methods Using a 1.5-T magnetic resonance imaging (MRI) system with a tailored cervical cord phased array coil, fast short-tau inversion recovery (fast-STIR) and MTR scans were obtained from 14 untreated patients with RRMS at baseline. Cervical cord MTR histograms were derived. Over the 18- month follow-up period, relapse rate was measured and disability assessed by the Expanded Disability Status Scale (EDSS) score.

Results Average cervical cord MTR was correlated with relapse rate (r= -0.56, P = 0.037). A moderate correlation (r values ranging from -0.33 to -0.36) between baseline cervical cord MTR metrics and EDSS changes over 18 months was also noted, albeit statistical significance was not reached (P = 0.26 and 0.21, respectively) perhaps because of the relatively small sample size.

Conclusions This study suggests that a ‘snapshot’ MT MRI assessment of the cervical cord may detect cervical cord tissue changes associated with short-term disease evolution in RRMS.

Key Words: cervical cord • clinical evolution • Expanded Disability Status Scale • magnetic resonance imaging • magnetization transfer ratio • multiple sclerosis

Multiple Sclerosis, Vol. 12, No. 5, 662-665 (2006)
DOI: 10.1177/1352458506070714


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