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Multiple Sclerosis, Vol. 12, No. 6, 747-753 (2006)
DOI: 10.1177/1352458506070928
© 2006 SAGE Publications

Myelin water imaging in multiple sclerosis: quantitative correlations with histopathology

C Laule

Department of Physics and Astronomy, Department of Radiology, University of British Columbia, University of British Columbia Hospital, Canada, claule{at}physics.ubc.ca

E Leung

Department of Pathology and Laboratory Medicine (Neuropathology), University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada

D KB Li

Department of Radiology, University of British Columbia, University of British Columbia Hospital, Canada

A L Traboulsee

Department of Medicine, University of British Columbia, University of British Columbia Hospital, Canada

D W Paty

Department of Medicine, University of British Columbia, University of British Columbia Hospital, Canada

A L MacKay

Department of Physics and Astronomy, Department of Radiology, University of British Columbia, University of British Columbia Hospital, Vancouver General Hospital, Vancouver BC, Canada

G RW Moore

Department of Pathology and Laboratory Medicine (Neuropathology), University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada

Various magnetic resonance (MR) techniques are used to study the pathological evolution of demyelinating diseases, such as multiple sclerosis (MS). However, few studies have validated MR derived measurements with histopathology. Here, we determine the correlation of myelin water imaging, an MR measure of myelin content, with quantitative histopathologic measures of myelin density. The multi-component T2 distribution of water was determined from 25 formalin-fixed MS brain samples using a multi-echo T2 relaxation MR experiment. The myelin water fraction (MWF), defined as T2 signal below 30 milliseconds divided by the total signal, was determined for various regions of interest and compared to Luxol fast blue (myelin stain) mean optical density (OD) for each sample. MWF had a strong correlation with myelin stain [mean (range) R2-/0.67 (0.45+ 0.92)], validating MWF as a measure of myelin density. This quantitative technique has many practical applications for the in vivo monitoring of demyelination and remyelination in a variety of disorders of myelin.

Key Words: brain • histopathology • MRI • multiple sclerosis • myelin • T2 relaxation


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