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Multiple sclerosis conference synopsis and discussion: cellular therapy for treatment of autoimmune diseases (October 2005)

Department of Neurology, City of Hope National Medical Center, Duarte, CA, USA, hopenshaw{at}coh.org

H L Atkins

Blood and Bone Marrow Transplant Program, The Ottawa Hospital, Ottawa, Canada

J T Chen

McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Montreal, Canada

P RM de Bittencourt

Unidade de Neurologia Clinica, Curitiba, Brazil

L M Griffith

Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

D A Kerr

Department of Neurology, Johns Hopkins Hospital, Baltimore, MD, USA

S A Khoury

Department of Neurology, Harvard University, Boston, MA, USA

P A Muraro

Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

R A Nash

Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA

R Saccardi

Bone Marrow Transplantation Unit, Careggi Hospital, University of Florence, Italy

At a conference held in October 2005, participants presented studies on high dose immunosuppression with hematopoietic cell transplant (HCT) for multiple sclerosis (MS), including neuroimmuno-logical and magnetic resonance imaging (MRI) mechanistic approaches, clinical registry reports, and ongoing or newly-designed protocols. A discussion panel considered questions on how to define success, timing of controlled clinical trials, difficulty in patient recruitment, and future direction of high dose therapy.

Key Words: cyclophosphamide • hematopoietic cell transplantation • immunosuppression • multiple sclerosis

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