This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (11) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Feuillet, L Articles by Pelletier, J Search for Related Content PubMed PubMed Citation Articles by Feuillet, L Articles by Pelletier, J Pubmed/NCBI databases Medline Plus Health Information Multiple Sclerosis Social Bookmarking                         What's this?

Early cognitive impairment in patients with clinically isolated syndrome suggestive of multiple sclerosis

F Reuter

B Audoin

I Malikova

Department of Neurology, Faculté de Médecine de Marseille, Université de la Méditerranée, Assistance Publique Hôpitaux de Marseille, Hôpital de La Timone, Marseille, France; CRMBM-CNRS 6612, Faculté de Médecine de Marseille, Université de la Méditerranée, Assistance Publique Hôpitaux de Marseille, Hôpital de La Timone, Marseille, France

K Barrau

Department of Public Health, Faculté de Médecine de Marseille, Université de la Méditerranée, Assistance Publique Hôpitaux de Marseille, Hôpital de La Timone, Marseille, France

A Ali Cherif

Department of Neurology, Faculté de Médecine de Marseille, Université de la Méditerranée, Assistance Publique Hôpitaux de Marseille, Hôpital de La Timone, Marseille, France

J Pelletier

Department of Neurology, Faculté de Médecine de Marseille, Université de la Méditerranée, Assistance Publique Hôpitaux de Marseille, Hôpital de La Timone, Marseille, France; CRMBM-CNRS 6612, Faculté de Médecine de Marseille, Université de la Méditerranée, Assistance Publique Hôpitaux de Marseille, Hôpital de La Timone, Marseille, France; Department of Neurology, CHU Timone, F-13385, Marseille, France; jean.pelletier{at}mail.ap-hm.fr

Cognitive impairment in patients with multiple sclerosis (MS) is a common occurrence and is generally fairly circumscribed. The prevalence of the cognitive deficits usually encountered could vary with the clinical course of the disease. To investigate whether the presence of cognitive impairment may occur in the very early stage of MS, we assessed the cognitive status of a group of 40 patients presenting with a recently diagnosed clinically isolated syndrome suggestive of MS (CISSMS), in comparison with 30 age-, sex-, and educational level-matched healthy control subjects. An extensive battery of neuropsychological tests was used to explore verbal and non-verbal memory, attention, concentration, speed of information processing, language and abstract reasoning. Patients with CISSMS had a significant, frequent (57%), and circumscribed cognitive impairment, focused on memory, speed of information processing, attention and executive functions.

Key Words: biomedical research • clinically isolated syndrome • cognitive impairment • multiple sclerosis • neurobehavioral manifestations • neuropsychological tests • PASAT

Multiple Sclerosis, Vol. 13, No. 1, 124-127 (2007)
DOI: 10.1177/1352458506071196


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				O. Garcea, A. Villa, F. Caceres, T. Adoni, M. Alegria, R. Barbosa Thomaz, R. Buzo, L. Llamas Lopez, and M. Rivera Kindel Early treatment of multiple sclerosis: a Latin American Experts Meeting Multiple Sclerosis, October 1, 2009; 15(3_suppl): S1 - S12. [Abstract] [PDF]

				F. Patti, M. Pia Amato, S. Bastianello, L. Caniatti, E. Di Monte, F. Lijoi, B. Goretti, S. Messina, O. Picconi, M. R. Tola, et al. Subcutaneous interferon beta-1a has a positive effect on cognitive performance in mildly disabled patients with relapsing--remitting multiple sclerosis: 2-year results from the COGIMUS study Therapeutic Advances in Neurological Disorders, March 1, 2009; 2(2): 67 - 77. [Abstract] [PDF]

				F Patti Cognitive impairment in multiple sclerosis Multiple Sclerosis, January 1, 2009; 15(1): 2 - 8. [Abstract] [PDF]

				P Nilsson, I Rorsman, E. Larsson, B Norrving, and M Sandberg-Wollheim Cognitive dysfunction 24-31 years after isolated optic neuritis Multiple Sclerosis, August 1, 2008; 14(7): 913 - 918. [Abstract] [PDF]

				B Audoin, F Reuter, M. Duong, I Malikova, S Confort-Gouny, A. Cherif, P. Cozzone, J Pelletier, and J. Ranjeva Efficiency of cognitive control recruitment in the very early stage of multiple sclerosis: a one-year fMRI follow-up study Multiple Sclerosis, July 1, 2008; 14(6): 786 - 792. [Abstract] [PDF]