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Multiple Sclerosis
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Increased CD8+ central memory T cells in patients with multiple sclerosis

Guang-Zhi Liu

Department of Neurology, Peking University People’s Hospital, 100044 Beijing, People’s Republic of China, guangzhi{at}public.bta.net.cn

Li-Bo Fang

Department of Neurology, Beijing Fuxing Hospital, Capital Medical University, 100038 Beijing, People’s Republic of China

Peter Hjelmström

Department of Clinical Science, Intervention and Technology, Karolinska Institute, SE-141 86 Stockholm, Sweden

Xu-Guang Gao

Department of Neurology, Peking University People’s Hospital, 100044 Beijing, People’s Republic of China

A T-cell-mediated autoimmune process against central nervous system myelin is believed to underlie the pathogenesis of multiple sclerosis (MS). Formation of immunological memory is based on the differentiation of naïve T cells to memory T cells after exposure to antigens and specific cytokines. The aim of this study was to analyse peripheral blood mononuclear cells in patients with MS for different T-cell subsets including naïve and memory T cells. Flow cytometry and enzyme-linked immunosorbent assay were used to analyse memory T-cell subsets and plasma concentration of interleukin-15 (IL-15) in peripheral blood of MS patients, patients with other neurological disorders and healthy controls. MS patients had a skewed distribution of T cells with an increased level of CD8+/CCR7+/CD45RA-central memory T cells (TCM) compared to healthy controls. In addition, MS patients showed significantly higher levels of plasma IL-15 than healthy controls did. Upregulated CD8+ TCM in MS patients may reflect a persistent chronic inflammatory response that may have been induced during early stages of the disease. This derangement may be important for maintaining chronic inflammation in MS.

Key Words: CCR7 • interleukin-15 • memory T cell • multiple sclerosis • peripheral blood

This version was published on March 1, 2007

Multiple Sclerosis, Vol. 13, No. 2, 149-155 (2007)
DOI: 10.1177/1352458506069246
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