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Profile of cytokine gene polymorphisms in Iranian multiple sclerosis patients

Immunogenetic Laboratory, Department of Immunology, Medical School, Tehran University of Medical Sciences, Tehran, Iran, amirzargar_ali{at}yahoo.com

F Khosravi

Immunogenetic Laboratory, Department of Immunology, Medical School, Tehran University of Medical Sciences, Tehran, Iran

S Dianat

Immunogenetic Laboratory, Department of Immunology, Medical School, Tehran University of Medical Sciences, Tehran, Iran

F Hushmand

Iranian Multiple Sclerosis Society and Department of Neurology, Medical School, Tehran University of Medical Sciences, Tehran, Iran

P Maryousef

Iranian Multiple Sclerosis Society and Department of Neurology, Medical School, Tehran University of Medical Sciences, Tehran, Iran

A R Foroushani

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

J Lotfi

Iranian Multiple Sclerosis Society and Department of Neurology, Medical School, Tehran University of Medical Sciences, Tehran, Iran

B Nikbin

Immunogenetic Laboratory, Department of Immunology, Medical School, Tehran University of Medical Sciences, Tehran, Iran

Background Cytokine gene polymorphisms have been extensively studied in association with different diseases. The role of cytokine gene polymorphisms in multiple sclerosis (MS), as a chronic immune-mediated neurodegenerative disease, has been previously reported.

Materials and methods DNA samples were collected from 44 patients with relapsing-remitting multiple sclerosis (RRMS) and 140 unrelated healthy subjects. All participants in this study were matched for ethnicity. Cytokine gene SNPs were determined using the PCR-SSP method.

Results and discussion We found no significant differences between MS patients and controls in most of the studied cytokine genes. Remarkable results were obtained for IL-2 GG-330 genotype (P =0.06), IL-6 C-174 allele (P =0.06), CG and GG genotypes (P <0.001), and GG (P =0.02) and CG (P <0.001) haplotypes, and TNF- A-238 allele (P <0.001), GG (P =0.003) and GA (P <0.001) haplotypes. These results suggest that polymorphic variations of these pro-inflammatory cytokines play an important role in susceptibility to MS.

Key Words: association • cytokine gene • Iranian population • multiple sclerosis • single nucleotide polymorphism

This version was published on March 1, 2007

Multiple Sclerosis, Vol. 13, No. 2, 253-255 (2007)
DOI: 10.1177/1352458506070237


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