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Multiple Sclerosis
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Effects of motor cortex rTMS on lower urinary tract dysfunction in multiple sclerosis

D Centonze

Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy, centonze{at}uniroma2.it

F Petta

Clinica Urologica, Università Tor Vergata, Rome, Italy

V Versace

Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy

S Rossi

Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy

F Torelli

Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy

C Prosperetti

Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy

St Rossi

Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy

G A Marfia

Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy

G Bernardi

Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy

G Koch

Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy

R Miano

Clinica Urologica, Università Tor Vergata, Rome, Italy

L Boffa

Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy

E Finazzi-Agrò

Clinica Urologica, Università Tor Vergata, Rome, Italy

We tested the effects of 5-Hz rTMS over the motor cortex in multiple sclerosis (MS) subjects complaining of lower urinary tract symptoms either in the filling or voiding phase. Our data show that motor cortex stimulation for five consecutive days over two weeks ameliorates the voiding phase of the micturition cycle, suggesting that enhancing corticospinal tract excitability might be useful to ameliorate detrusor contraction and/or urethral sphincter relaxation in MS patients with bladder dysfunction.

Key Words: cortex • detrusor overactivity • motor cortex • rTMS • voiding dysfunction

This version was published on March 1, 2007

Multiple Sclerosis, Vol. 13, No. 2, 269-271 (2007)
DOI: 10.1177/1352458506070729
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