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Multiple Sclerosis
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Impact of depression and disability on quality of life in Iranian patients with multiple sclerosis

P Ayatollahi

Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran 14114, Iran

S Nafissi

Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran 14114, Iran, nafisi{at}sina.tums.ac.ir

M R Eshraghian

Department of Biostatistics and Epidemiology, Tehran University of Medical Sciences, Tehran 14176, Iran

H Kaviani

Psychiatry and Psychology Research Center, Rouzbeh Hospital, Tehran University of Medical Sciences, Tehran 13185, Iran

A Tarazi

Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran 14114, Iran

Multiple sclerosis (MS) can influence all aspects of a patient’s health. This study determines the main factors affecting quality of life (QoL) in Iranian MS patients. QoL (Multiple Sclerosis Impact Scale; MSIS-29), disability (Expanded Disability Status Scale; EDSS) and depression (Beck Depression Inventory; BDI) were assessed in 106 MS patients. EDSS, clinical course and MS duration significantly correlated with physical MSIS-29. Depression highly correlated with both physical and psychological MSIS-29. Regression analyses showed that depression and EDSS predicted physical health. Psychological health was predicted by depression. These findings highlight that depression and physical disability strongly influence QoL in Iranian MS patients.

Key Words: depression • disability • multiple sclerosis • quality of life

This version was published on March 1, 2007

Multiple Sclerosis, Vol. 13, No. 2, 275-277 (2007)
DOI: 10.1177/1352458506070960
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