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Multiple Sclerosis
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Clinical and laboratory features of neuromyelitis optica with oligoclonal IgG bands

M. Nakamura

Department of Neurology, Tohoku University School of Medicine, Aoba-ku, Sendai 980-8574, Japan,mnakamura{at}em.neurol.med.tohoku.ac.jp

I. Nakashima

Department of Neurology, Tohoku University School of Medicine, Aoba-ku, Sendai 980-8574, Japan

S. Sato

Department of Neurology, Kohnan Hospital, Sendai, Japan

I. Miyazawa

Department of Neurology, Tohoku University School of Medicine, Aoba-ku, Sendai 980-8574, Japan

K. Fujihara

Department of Neurology, Tohoku University School of Medicine, Aoba-ku, Sendai 980-8574, Japan

Y. Itoyama

Department of Neurology, Tohoku University School of Medicine, Aoba-ku, Sendai 980-8574, Japan

Of 23 neuromyelitis optica (NMO) cases, we found two cases with oligoclonal IgG bands (OBs). Both patients were positive for NMO-IgG. Their common features were long disease duration and co-existing autoimmune diseases (myasthenia gravis and sicca syndrome). Although OBs are mostly negative in NMO, which distinguishes it from multiple sclerosis (MS), they can be positive by long-standing autoimmunity, which may not be directly related to NMO. Multiple Sclerosis 2007; 13: 332-335. http://msj.sagepub.com

Key Words: co-existing autoimmune diseases • myasthenia gravis • neuromyelitis optica • NMO-IgG • oligoclonal IgG bands • sicca syndrome

Multiple Sclerosis, Vol. 13, No. 3, 332-335 (2007)
DOI: 10.1177/13524585070130030201
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