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Subtle upper limb impairment in asymptomatic multiple sclerosis subjects

Department of Neurology, Hospital 'P Antero Micone', Genova, Italy,csolaro{at}libero.it

G. Brichetto

Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy

M. Casadio

Department of Informatics, Systems and Telematics, University of Genova, Genova, Italy

L. Roccatagliata

Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy

P. Ruggiu

Department of Informatics, Systems and Telematics, University of Genova, Genova, Italy

G.L. Mancardi

Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy, Center for Excellence for Biomedical Research, University of Genova, Genova, Italy

P.G. Morasso

Department of Informatics, Systems and Telematics, University of Genova, Genova, Italy

P. Tanganelli

Department of Neurology, Hospital 'P Antero Micone', Genova, Italy

V. Sanguineti

Department of Informatics, Systems and Telematics, University of Genova, Genova, Italy

We evaluated upper limb function in multiple sclerosis (MS) subjects (11 clinically definite MS patients and seven clinically isolated syndrome (CIS) subjects), with a normal upper limb standard neurological examination. Subjects performed center-out reaching movements under visual control, with and without vision of the hand. Their movements were recorded through a digitizing tablet. Motor performance was also related to lesion load, estimated from magnetic resonance imaging (MRI). We found that in MS and CIS subjects, under the hand vision condition, movements were significantly less smooth, and had a less symmetric speed profile. However, the observed impairment did not correlate with MRI findings. This result may be interpreted as evidence of a compensatory strategy, elicited by subtle alterations in sensorimotor control. Multiple Sclerosis 2007; 13: 428-432. http://msj.sagepub.com

Key Words: asymptomatic • digitizing tablet • multiple sclerosis • upper limb • sensorimotor control

This version was published on April 1, 2007

Multiple Sclerosis, Vol. 13, No. 3, 428-432 (2007)
DOI: 10.1177/1352458506069926


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