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Multiple Sclerosis
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UCP2 and mitochondrial haplogroups as a multiple sclerosis risk factor

D. Otaegui

Unidad Experimental, Hospital Donostia, dotaegui{at}gmail.com

A. Saenz

Unidad Experimental, Hospital Donostia

J. Ruiacgrz-Martiacgrnez

Servicio de Neurología, Hospital de Mendaro

J. Olaskoaga

Servicio de Neurología, Hospital Donostia

A. López de Munain

Unidad Experimental, Hospital Donostia, Servicio de Neurología, Hospital Donostia

In the actual scenario of the search for further genetic susceptibility factors, a recent paper noted an SNP in the UCP2 gene as a multiple sclerosis (MS) risk factor. UCP2 is a member of the mitochondrial proton transport family, which uncouples proton entry in the mitochondrial matrix from ATP synthesis. mtDNA haplogroups are also associated with ATP production, and are linked with mitochondrial proton transport. In this work, we studied the UCP2 SNP and the mitochondrial haplogroups distribution in a Spanish MS population, with a population sub-group of Basque-origin patients. Our results confirm the link between UCP2 SNP and MS, and show a slight relation between this SNP and mitochondrial haplogroups. Multiple Sclerosis 2007; 13: 454-458. http://msj.sagepub.com

Key Words: association • Basque • mitochondrial haplogroups • multiple sclerosis • Multiple Sclerosis Severity Score • UCP2

This version was published on May 1, 2007

Multiple Sclerosis, Vol. 13, No. 4, 454-458 (2007)
DOI: 10.1177/1352458506070454
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