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Voxel-based analysis of grey matter magnetization transfer ratio maps in early relapsing remitting multiple sclerosis

NMR Research Unit, Institute of Neurology, University College London, London, UK, Department of Neuroinflammation, Rehabilitation and Brain Injury, Institute of Neurology, University College London, London, UK, Centre de Résonance Magnétique Biologique et Médicale (CRMBM) and Service de Neurologie, Hôpital de la Timone, Marseille, France

G. Davies

NMR Research Unit, Institute of Neurology, University College London, London, UK, Department of Neuroinflammation, Rehabilitation and Brain Injury, Institute of Neurology, University College London, London, UK

W. Rashid

NMR Research Unit, Institute of Neurology, University College London, London, UK, Department of Neuroinflammation, Rehabilitation and Brain Injury, Institute of Neurology, University College London, London, UK

L. Fisniku

NMR Research Unit, Institute of Neurology, University College London, London, UK, Department of Neuroinflammation, Rehabilitation and Brain Injury, Institute of Neurology, University College London, London, UK

A.J. Thompson

NMR Research Unit, Institute of Neurology, University College London, London, UK, Department of Headache, Rehabilitation and Brain Injury, Institute of Neurology, University College London, London, UK

D.H. Miller

NMR Research Group, Institute of Neurology, Queen Square, London, WC1N 3BG, UK, d.miller{at}ion.ucl.ac.uk

Previous studies using magnetization transfer ratio (MTR) histogram analysis have demonstrated the existence of global grey matter (GM) abnormalities in patients with early relapsing-remitting multiple sclerosis (RRMS). However, MTR histogram analysis does not provide any information on the localization of the morphological changes within the GM. The aim of this study was to investigate the localization of GM injury in early RRMS, performing voxel-based analysis of GM MTR maps. Statistical mapping analysis of GM MTR maps was performed in a group of 38 patients with early RRMS and 45 healthy controls. Between-group comparisons (P<0.05, corrected for multiple comparisons) demonstrated significant GM MTR decrease in patients located in the bilateral lenticular nuclei, the bilateral insula, the left posterior cingulate cortex, and the right orbitofrontal cortex. To limit the potential confounding effect of regional GM atrophy, the percentages of GM were assessed in the regions showing significant MTR decrease, and no GM atrophy was evidenced in these regions. This study demonstrates that several GM regions are commonly affected in patients with early RRMS. Predominant involvement of these structures may be partly related to their vulnerability to anterograde or retrograde degeneration from transected axons in the white matter and/or to the predominant localization of GM demyelinating lesions in such regions. Multiple Sclerosis 2007; 13: 483-489. http://msj.sagepub.com

Key Words: early RRMS • grey matter • MTR • voxel-based analysis

This version was published on May 1, 2007

Multiple Sclerosis, Vol. 13, No. 4, 483-489 (2007)
DOI: 10.1177/1352458506070450


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