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This version was published on June 1, 2007
Multiple Sclerosis, Vol. 13, No. 5, 578-583 (2007)
DOI: 10.1177/1352458506072667

Human herpesvirus-6 and multiple sclerosis: relapsing-remitting versus secondary progressive

Roverto Alvarez-Lafuente

Servicio de Neurología, Hospital Clínico San Carlos, Madrid 28040, Spain, labesmul{at}hcsc.es

Virginia de las Heras

Servicio de Neurología, Hospital Clínico San Carlos, Madrid 28040, Spain

Marta Garcia-Montojo

Servicio de Neurología, Hospital Clínico San Carlos, Madrid 28040, Spain

Manuel Bartolome

Servicio de Neurología, Hospital Clínico San Carlos, Madrid 28040, Spain

Rafael Arroyo

Servicio de Neurología, Hospital Clínico San Carlos, Madrid 28040, Spain

Recently, it has been suggested that human herpesvirus-6 (HHV-6) may play a role in the pathogenesis of relapsing-remitting multiple sclerosis (RRMS), but there is not enough information related to the role of HHV-6 in secondary-progressive MS (SPMS). To address this question, we evaluated HHV-6 prevalence, active viral replication and viral load measured by quantitative real-time PCR, in DNA and mRNA extracted from peripheral blood mononuclear cells (PBMCs) and DNA extracted from serum; the samples were collected from 31 SPMS and 31 RRMS patients in a one-year follow-up study, and sex- and age-matched controls. The results were as follows: i) We found a statistical significant difference in HHV-6 DNA prevalences between RRMS and SPMS patients in: DNA extracted from PBMCs (P= 0.027), DNA extracted from serum (P= 0.010) and mRNA extracted from PBMCs (P =0.010). When we compared HHV-6 prevalences from RRMS patients in relapse and in remission with those from SPMS patients, we only achieved a statistical significance for the relapses (P=0.003 in DNA from PBMCs, and P<0.001 in DNA from serum samples and mRNA from PBMCs). ii) We only found HHV-6 variant A among HHV-6 positive samples in serum. iii) We did not find any difference in HHV-6 viral loads. These results suggest that HHV-6A does not play an active role in SPMS, while this virus may contribute to the pathogenesis of RRMS triggering MS attacks in a subset of patients. Multiple Sclerosis 2007; 13: 578-583. http://msj.sagepub.com

Key Words: HHV-6 • multiple sclerosis • PCR • relapsing-remitting • secondary progressive


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