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This version was published on June 1, 2007
Multiple Sclerosis, Vol. 13, No. 5, 584-589 (2007)
DOI: 10.1177/1352458506071790

A follow-up study of Nordic multiple sclerosis candidate gene regions

P. Datta

Danish Multiple Sclerosis Research Centre, Copenhagen, Denmark

H.F. Harbo

Institute of Immunology, Faculty Division Rikshospitalet University of Oslo, Oslo, Norway, h.f.harbo{at}medisin.uio.no, Department of Neurology, Ullevål University Hospital, Oslo, Norway

L.P. Ryder

Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark

E. Akesson

Department of Neurology, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden

J. Benedikz

Multiple Sclerosis Rehabilitation and Diagnostic Center of the MS Society of Iceland, Reykjavik, Iceland

E.G. Celius

Department of Neurology, Ullevål University Hospital, Oslo, Norway

O. Andersen

Department of Neurology, Gothenburg University Hospital, Gothenburg, Sweden

K.-M. Myhr

Department of Neurology, Haukeland University Hospital and Department of Clinical Medicine, Section for Neurology, University of Bergen, Bergen, Norway

M. Sandberg-Wollheim

Department of Neurology, Lund University Hospital, Lund, Sweden

J. Hillert

Department of Neurology, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden

A. Svejgaard

Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark

P.S. Sorensen

Danish Multiple Sclerosis Research Centre, Copenhagen, Denmark

A. Spurkland

Department of Anatomy, Institute of Basal Medical Sciences, University of Oslo, Oslo, Norway

A. Oturai

Danish Multiple Sclerosis Research Centre, Copenhagen, Denmark

In this study, the results from three Nordic linkage disequilibrium screens in multiple sclerosis (MS) were investigated, in a new sample set of 314 Nordic MS trios from Denmark, Norway, Sweden and Iceland. Among 30 non-HLA and two HLA microsatellite markers individually genotyped, eight markers displayed distorted transmission with uncorrected P-value <0.05, ranked in this order: D6S2443 (6p21.32, HLA class II) (P corrected =0.01), D2S2201 (2p24), D19S552 (19q13), D3S3584 (3q21), D17S975 (17q11), D1S2627 (1p22), D6S273 (6p21.33, HLA class III) and D12S1051 (12q23). These non-HLA regions need further investigation as possible MS candidate gene regions in our population. Multiple Sclerosis 2007; 13: 584-589. http://msj.sagepub.com

Key Words: candidate regions • GAMES • genetics • HLA • LD screens • multiple sclerosis • Nordic countries


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